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    Dennd2d DENN domain containing 2D [ Mus musculus (house mouse) ]

    Gene ID: 72121, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dennd2dprovided by MGI
    Official Full Name
    DENN domain containing 2Dprovided by MGI
    Primary source
    MGI:MGI:2181193
    See related
    Ensembl:ENSMUSG00000027901 AllianceGenome:MGI:2181193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010308M01Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human DENND2D (DENN domain containing 2D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 8.3), large intestine adult (RPKM 7.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dennd2d in Genome Data Viewer
    Location:
    3 F2.3; 3 46.49 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106389745..106410346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106482431..106503030)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08646 Neighboring gene chitinase 3-like 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08647 Neighboring gene chitinase-like 6 Neighboring gene STARR-seq mESC enhancer starr_08648 Neighboring gene STARR-positive B cell enhancer ABC_E6101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106252568-106252751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106264918-106265101 Neighboring gene RIKEN cDNA 2010016I18 gene Neighboring gene STARR-seq mESC enhancer starr_08649 Neighboring gene choline/ethanolaminephosphotransferase 1 Neighboring gene STARR-seq mESC enhancer starr_08650 Neighboring gene STARR-positive B cell enhancer ABC_E6102 Neighboring gene DNA-damage regulated autophagy modulator 2 Neighboring gene STARR-seq mESC enhancer starr_08651 Neighboring gene STARR-seq mESC enhancer starr_08652 Neighboring gene STARR-seq mESC enhancer starr_08653 Neighboring gene ligand dependent nuclear receptor interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2D
    Names
    DENN/MADD domain containing 2D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093754.2 → NP_001087223.1  DENN domain-containing protein 2D isoform 2

      See identical proteins and their annotated locations for NP_001087223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140380, AK008546
      Consensus CDS
      CCDS51040.1
      UniProtKB/Swiss-Prot
      Q3U028, Q91VV4, Q9D831
      Related
      ENSMUSP00000029508.5, ENSMUST00000029508.11
      Conserved Domains (3) summary
      smart00801
      Location:369 → 434
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:47 → 139
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:147 → 330
      DENN; DENN (AEX-3) domain

    2. NM_001278941.1 → NP_001265870.1  DENN domain-containing protein 2D isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC140380, AK008546, AK050033
      UniProtKB/Swiss-Prot
      Q91VV4
      Conserved Domains (2) summary
      smart00801
      Location:192 → 257
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:4 → 153
      DENN; DENN (AEX-3) domain

    3. NM_028110.2 → NP_082386.2  DENN domain-containing protein 2D isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC140380
      Consensus CDS
      CCDS17722.2
      UniProtKB/Swiss-Prot
      Q3U028, Q91VV4, Q9D831
      UniProtKB/TrEMBL
      S4R219
      Related
      ENSMUSP00000138462.2, ENSMUST00000183271.2
      Conserved Domains (3) summary
      smart00801
      Location:379 → 444
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:57 → 149
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:157 → 340
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106389745..106410346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252838.2 → XP_030108698.1  DENN domain-containing protein 2D isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:318 → 383
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:96 → 279
      DENN; DENN (AEX-3) domain
      cl04085
      Location:66 → 88
      uDENN; uDENN domain

    RNA

    1. XR_003954399.2 RNA Sequence

    2. XR_003954396.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VV4.1 GenPept UniProtKB/Swiss-Prot:Q91VV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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