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    Trnau1ap tRNA selenocysteine 1 associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 71787, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trnau1approvided by MGI
    Official Full Name
    tRNA selenocysteine 1 associated protein 1provided by MGI
    Primary source
    MGI:MGI:1919037
    See related
    Ensembl:ENSMUSG00000028898 AllianceGenome:MGI:1919037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Secp43; Trspap1; 1110007F05Rik; WI1-2643G14.2
    Summary
    Predicted to enable tRNA binding activity. Involved in selenocysteine incorporation. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.1), CNS E11.5 (RPKM 6.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trnau1ap in Genome Data Viewer
    Location:
    4 D2.3; 4 65.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132039074..132058007, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132311763..132330696, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7994 Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 61 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene regulator of chromosome condensation 1 Neighboring gene CRISPRi-validated cis-regulatory element for Rcc1 and Trnau1ap Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA host gene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap). Mahdi Y, et al. PLoS One, 2015. PMID 26043259, Free PMC Article
    2. Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway. Hu X, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29758194
    3. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. Xu XM, et al. J Biol Chem, 2005 Dec 16. PMID 16230358
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of Trnau1ap reduced cell migration and proliferation. Knockdown of Trnau1ap blocked the PI3K/Akt signaling pathway.
      Title: Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
    2. These findings suggest that the targeted domains in the SECp43 protein are not essential for selenoprotein biosynthesis in hepatocytes and neurons.
      Title: Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).
    3. SECp43 and SLA have roles in selenoprotein synthesis
      Title: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA selenocysteine 1-associated protein 1
    Names
    tRNA selenocysteine-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027925.3 → NP_082201.2  tRNA selenocysteine 1-associated protein 1

      See identical proteins and their annotated locations for NP_082201.2

      Status: VALIDATED

      Source sequence(s)
      AK152986, BC099594, BY283216, CJ166630
      Consensus CDS
      CCDS18722.1
      UniProtKB/Swiss-Prot
      Q05DN9, Q4FZE9, Q7TMM7, Q80VC6
      Related
      ENSMUSP00000030730.8, ENSMUST00000030730.14
      Conserved Domains (2) summary
      cd12610
      Location:4 → 87
      RRM1_SECp43; RNA recognition motif 1 in tRNA selenocysteine-associated protein 1 (SECp43)
      cd12612
      Location:95 → 176
      RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132039074..132058007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539180.4 → XP_006539243.1  tRNA selenocysteine 1-associated protein 1 isoform X1

      Conserved Domains (2) summary
      cd12612
      Location:29 → 110
      RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)
      pfam17654
      Location:139 → 218
      Trnau1ap; Selenocysteine tRNA 1 associated proteins

    2. XM_011250332.3 → XP_011248634.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011248634.1

      Related
      ENSMUST00000146166.8
      Conserved Domains (2) summary
      pfam17654
      Location:95 → 174
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:1 → 66
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_011250334.3 → XP_011248636.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011248636.1

      Conserved Domains (2) summary
      pfam17654
      Location:95 → 174
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:1 → 66
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_030253783.2 → XP_030109643.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam17654
      Location:95 → 174
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:1 → 66
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_017320388.3 → XP_017175877.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam17654
      Location:95 → 174
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:1 → 66
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_030253782.2 → XP_030109642.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam17654
      Location:95 → 174
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:1 → 66
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_030253784.1 → XP_030109644.1  tRNA selenocysteine 1-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam17654
      Location:95 → 174
      Trnau1ap; Selenocysteine tRNA 1 associated proteins
      cl17169
      Location:1 → 66
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VC6.2 GenPept UniProtKB/Swiss-Prot:Q80VC6

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