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    Mus81 MUS81 structure-specific endonuclease subunit [ Mus musculus (house mouse) ]

    Gene ID: 71711, updated on 18-Sep-2024

    Summary

    Official Symbol
    Mus81provided by MGI
    Official Full Name
    MUS81 structure-specific endonuclease subunitprovided by MGI
    Primary source
    MGI:MGI:1918961
    See related
    Ensembl:ENSMUSG00000024906 AllianceGenome:MGI:1918961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200008A18Rik
    Summary
    Predicted to enable 3'-flap endonuclease activity. Predicted to be involved in DNA recombination; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process, endonucleolytic; DNA repair; and response to intra-S DNA damage checkpoint signaling. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.3), cerebellum adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mus81 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5532589..5538461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5482561..5488389, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5488369-5488552 Neighboring gene STARR-positive B cell enhancer ABC_E779 Neighboring gene STARR-positive B cell enhancer ABC_E8730 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5491370-5491523 Neighboring gene cofilin 1, non-muscle Neighboring gene sorting nexin 32 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3'-flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables crossover junction DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of endodeoxyribonuclease complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear replication fork NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    crossover junction endonuclease MUS81
    Names
    MUS81 endonuclease homolog
    NP_082153.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027877.4NP_082153.3  crossover junction endonuclease MUS81

      See identical proteins and their annotated locations for NP_082153.3

      Status: VALIDATED

      Source sequence(s)
      AA014278, AC126029, AK004647, AK145858, BY208661
      Consensus CDS
      CCDS29467.1
      UniProtKB/Swiss-Prot
      Q8R356, Q91ZJ0
      UniProtKB/TrEMBL
      F8WIN9
      Related
      ENSMUSP00000114895.2, ENSMUST00000124334.8
      Conserved Domains (2) summary
      COG1948
      Location:248515
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      pfam02732
      Location:273415
      ERCC4; ERCC4 domain

    RNA

    1. NR_153768.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126029, AK145858
      Related
      ENSMUST00000025841.4
    2. NR_153769.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126029

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5532589..5538461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952818.2 RNA Sequence

    2. XR_003952819.2 RNA Sequence

    3. XR_003952817.2 RNA Sequence