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    Clec12b C-type lectin domain family 12, member B [ Mus musculus (house mouse) ]

    Gene ID: 71183, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Clec12bprovided by MGI
    Official Full Name
    C-type lectin domain family 12, member Bprovided by MGI
    Primary source
    MGI:MGI:1918433
    See related
    Ensembl:ENSMUSG00000030158 AllianceGenome:MGI:1918433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933425B16Rik
    Summary
    Predicted to enable protein phosphatase binding activity and signaling receptor inhibitor activity. Predicted to be involved in several processes, including melanocyte proliferation; natural killer cell inhibitory signaling pathway; and regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC12B (C-type lectin domain family 12 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.4), lung adult (RPKM 1.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clec12b in Genome Data Viewer
    Location:
    6 F3; 6 63.28 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129352476..129404597, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129375513..129427634, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene C-type lectin domain family 12, member a Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene STARR-positive B cell enhancer ABC_E6498 Neighboring gene STARR-positive B cell enhancer ABC_E4872 Neighboring gene C-type lectin domain family 1, member b Neighboring gene C-type lectin domain family 9, member a Neighboring gene STARR-positive B cell enhancer mm9_chr6:129384284-129384585 Neighboring gene C-type lectin domain family 1, member a Neighboring gene STARR-seq mESC enhancer starr_17480 Neighboring gene predicted gene, 45969 Neighboring gene C-type lectin domain family 7, member a Neighboring gene oxidized low density lipoprotein (lectin-like) receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components. Kottom TJ, et al. J Med Microbiol, 2023 Jun. PMID 37294293
    2. Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells. Iijima A, et al. Biochem Biophys Res Commun, 2021 Jul 5. PMID 34020140
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components.
      Title: CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components.
    2. Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
      Title: Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in melanocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in natural killer cell inhibitory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in natural killer cell inhibitory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 12 member B
    Names
    macrophage antigen h

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204223.1 → NP_001191152.1  C-type lectin domain family 12 member B

      See identical proteins and their annotated locations for NP_001191152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC138620
      Consensus CDS
      CCDS51922.1
      UniProtKB/Swiss-Prot
      Q149M0, Q9D403
      UniProtKB/TrEMBL
      A0A0R4J0A7
      Related
      ENSMUSP00000107713.4, ENSMUST00000112082.9
      Conserved Domains (1) summary
      cd03593
      Location:142 → 264
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_027709.2 → NP_081985.1  C-type lectin domain family 12 member B

      See identical proteins and their annotated locations for NP_081985.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK016908, AV319772
      Consensus CDS
      CCDS51922.1
      UniProtKB/Swiss-Prot
      Q149M0, Q9D403
      UniProtKB/TrEMBL
      A0A0R4J0A7
      Related
      ENSMUSP00000032261.7, ENSMUST00000032261.9
      Conserved Domains (1) summary
      cd03593
      Location:142 → 264
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129352476..129404597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241466.1 → XP_011239768.1  C-type lectin domain family 12 member B isoform X1

      See identical proteins and their annotated locations for XP_011239768.1

      UniProtKB/Swiss-Prot
      Q149M0, Q9D403
      Conserved Domains (1) summary
      cd03593
      Location:145 → 267
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. XM_006506612.2 → XP_006506675.1  C-type lectin domain family 12 member B isoform X2

      See identical proteins and their annotated locations for XP_006506675.1

      UniProtKB/Swiss-Prot
      Q149M0, Q9D403
      UniProtKB/TrEMBL
      A0A0R4J0A7
      Conserved Domains (1) summary
      cd03593
      Location:142 → 264
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q149M0.1 GenPept UniProtKB/Swiss-Prot:Q149M0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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