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    SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709060, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SAMHD1provided by VGNC
    Official Full Name
    SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1provided by VGNC
    Primary source
    VGNC:VGNC:77020
    Locus tag
    EGK_02438
    See related
    Ensembl:ENSMMUG00000002091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SAMHD1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (72157904..72218852, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (27109166..27166997)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene microtubule crosslinking factor 2 Neighboring gene TBC/LysM-associated domain containing 2 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene RB transcriptional corepressor like 1 Neighboring gene maestro heat like repeat family member 8 Neighboring gene ribophorin II

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X. Coggins SA, et al. J Biol Chem, 2020 Dec 11. PMID 33008888, Free PMC Article
    2. The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. Shingai M, et al. PLoS Pathog, 2015 May. PMID 25996507, Free PMC Article
    3. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Lahouassa H, et al. Nat Immunol, 2012 Feb 12. PMID 22327569, Free PMC Article
    4. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Lim ES, et al. Cell Host Microbe, 2012 Feb 16. PMID 22284954, Free PMC Article
    5. Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Laguette N, et al. Cell Host Microbe, 2012 Feb 16. PMID 22305291, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
      Title: Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
    2. Data suggest that critical role of vpx (Simian immunodeficiency virus vpx protein) in vivo/in vitro is to promote degradation of SAMHD1 in memory CD4+ T-lymphocytes, generating high levels of plasma viremia and induction of immunodeficiency.
      Title: The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
    3. Vpx prevented the SAMHD1-mediated decrease in dNTP concentration and induced the degradation of human and rhesus macaque SAMHD1 but had no effect on mouse SAMHD1
      Title: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dGTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dGTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deoxynucleoside triphosphate triphosphohydrolase SAMHD1
    Names
    SAM domain and HD domain-containing protein 1
    NP_001258571.1
    XP_028683151.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271642.1 → NP_001258571.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1

      See identical proteins and their annotated locations for NP_001258571.1

      Status: VALIDATED

      Source sequence(s)
      JN936895
      UniProtKB/TrEMBL
      A0A5F8AAM4, A0A8J8YMA9, G7N4W9, K4K7T3
      Related
      ENSMMUP00000074436.1, ENSMMUT00000084647.1
      Conserved Domains (2) summary
      cd09508
      Location:41 → 110
      SAM_HD; SAM domain of HD-phosphohydrolase
      COG1078
      Location:115 → 504
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      72157904..72218852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028827318.1 → XP_028683151.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

      UniProtKB/TrEMBL
      K4K7T3
      Conserved Domains (1) summary
      COG1078
      Location:49 → 438
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials