DIO3 iodothyronine deiodinase 3 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: DIO3
Gene description: iodothyronine deiodinase 3
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Summary: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. It is highly expressed in placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It thus plays a critical role in mammalian development by regulating circulating fetal thyroid hormone concentration. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (163784669..163786770)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (163900878..163902979)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH103871 (e-PCR)
- UniSTS:98196

STS-S79854 (e-PCR)
- UniSTS:34780

MARC_54596-54595:1155067325:1 (e-PCR)
- UniSTS:508155

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thyroxine 5'-deiodinase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thyroxine 5-deiodinase

Names: deiodinase, iodothyronine type III

NP_001116121.2

EC 1.21.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122649.3 → NP_001116121.2 thyroxine 5-deiodinase

Status: REVIEWED

Source sequence(s)

QNVO02000421

Conserved Domains (1) summary

pfam00837
Location:39 → 293

T4_deiodinase; Iodothyronine deiodinase