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    Igsf23 immunoglobulin superfamily, member 23 [ Mus musculus (house mouse) ]

    Gene ID: 70080, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Igsf23provided by MGI
    Official Full Name
    immunoglobulin superfamily, member 23provided by MGI
    Primary source
    MGI:MGI:1917330
    See related
    Ensembl:ENSMUSG00000040498 AllianceGenome:MGI:1917330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210010C17Rik
    Summary
    Predicted to be involved in osteoclast differentiation. Predicted to be located in plasma membrane. Orthologous to human IGSF23 (immunoglobulin superfamily member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 65.3), small intestine adult (RPKM 50.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Igsf23 in Genome Data Viewer
    Location:
    7 A3; 7 9.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19671230..19687579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19937305..19953654, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene poliovirus receptor Neighboring gene ribosomal protein L14 pseudogene Neighboring gene predicted gene 16251 Neighboring gene STARR-seq mESC enhancer starr_18231 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20517919-20518126 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20518638-20518747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20520941-20521094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20525341-20525450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20525675-20525828 Neighboring gene ribosomal protein L7A, pseudogene 8 Neighboring gene CEA cell adhesion molecule 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364024.1 → NP_001350953.1  immunoglobulin superfamily member 23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK033677, AK135657
      Conserved Domains (1) summary
      smart00408
      Location:125 → 174
      IGc2; Immunoglobulin C-2 Type

    2. NM_001364025.1 → NP_001350954.1  immunoglobulin superfamily member 23 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130530, AC149085
      Consensus CDS
      CCDS90175.1
      UniProtKB/TrEMBL
      A0A140LJ51
      Related
      ENSMUSP00000147077.2, ENSMUST00000208974.2
      Conserved Domains (1) summary
      smart00408
      Location:79 → 128
      IGc2; Immunoglobulin C-2 Type

    3. NM_027308.2 → NP_081584.1  immunoglobulin superfamily member 23 isoform 1 precursor

      See identical proteins and their annotated locations for NP_081584.1

      Status: VALIDATED

      Source sequence(s)
      AK033677
      Consensus CDS
      CCDS52065.1
      UniProtKB/Swiss-Prot
      B2RTN2
      Related
      ENSMUSP00000047914.7, ENSMUST00000043440.8
      Conserved Domains (1) summary
      smart00408
      Location:117 → 166
      IGc2; Immunoglobulin C-2 Type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19671230..19687579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540355.4 → XP_006540418.1  immunoglobulin superfamily member 23 isoform X2

      Conserved Domains (1) summary
      smart00408
      Location:47 → 96
      IGc2; Immunoglobulin C-2 Type

    2. XM_006540354.4 → XP_006540417.1  immunoglobulin superfamily member 23 isoform X1

      Conserved Domains (1) summary
      smart00408
      Location:117 → 166
      IGc2; Immunoglobulin C-2 Type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RTN2.1 GenPept UniProtKB/Swiss-Prot:B2RTN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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