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    Scrn1 secernin 1 [ Mus musculus (house mouse) ]

    Gene ID: 69938, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Scrn1provided by MGI
    Official Full Name
    secernin 1provided by MGI
    Primary source
    MGI:MGI:1917188
    See related
    Ensembl:ENSMUSG00000019124 AllianceGenome:MGI:1917188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SES1; mKIAA0193; 2810019K23Rik; 6330535A03Rik
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in exocytosis and regulation of synaptic vesicle cycle. Predicted to be located in nuclear membrane. Predicted to be active in presynapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system ganglion; reproductive system; and retina. Orthologous to human SCRN1 (secernin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 16.2), frontal lobe adult (RPKM 12.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scrn1 in Genome Data Viewer
    Location:
    6 B3; 6 26.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54451813..54543332, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54474794..54566517, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene STARR-seq mESC enhancer starr_15949 Neighboring gene STARR-seq mESC enhancer starr_15950 Neighboring gene proline rich 15 Neighboring gene predicted gene, 34169 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene predicted gene, 52863 Neighboring gene FK506 binding protein 14 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene predicted gene, 34249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1. Yang X, et al. Mol Neurobiol, 2023 Mar. PMID 36437381
    2. The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice. Crisol BM, et al. Life Sci, 2018 Feb 1. PMID 29273527
    3. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Houston BJ, et al. Dev Dyn, 2021 Jul. PMID 33442887, Free PMC Article
    4. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Way G, et al. Mol Biol Cell, 2002 Sep. PMID 12221138, Free PMC Article
    5. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Bouma GJ, et al. Biol Reprod, 2010 Feb. PMID 19864314, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1.
      Title: Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1.
    2. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse.
      Title: The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse.
    3. While acute aerobic exercise increased Sesn1 accumulation and induced a discrete augment of Sesn2 protein content and AMPK threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 and Sesn2 as well as of AMPK threonine phosphorylation in the quadriceps muscles of C57BL/6J mice.
      Title: The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secernin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417702.1 → NP_001404631.1  secernin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8

    2. NM_001417703.1 → NP_001404632.1  secernin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8

    3. NM_001417704.1 → NP_001404633.1  secernin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8

    4. NM_001417705.1 → NP_001404634.1  secernin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC087841

    5. NM_001417706.1 → NP_001404635.1  secernin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC087841
      Related
      ENSMUSP00000145469.2, ENSMUST00000203800.2

    6. NM_027268.3 → NP_081544.1  secernin-1 isoform a

      See identical proteins and their annotated locations for NP_081544.1

      Status: VALIDATED

      Source sequence(s)
      AC084800, AC087841
      Consensus CDS
      CCDS20156.1
      UniProtKB/Swiss-Prot
      Q3UKR2, Q8CCL3, Q9CZC8
      Related
      ENSMUSP00000019268.5, ENSMUST00000019268.11
      Conserved Domains (1) summary
      cl00467
      Location:18 → 227
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54451813..54543332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZC8.1 GenPept UniProtKB/Swiss-Prot:Q9CZC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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