TRGV9 T cell receptor gamma variable 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRGV9provided by HGNC
Official Full Name: T cell receptor gamma variable 9provided by HGNC
Primary source: HGNC:HGNC:12295
See related: Ensembl:ENSG00000211695 IMGT/GENE-DB:TRGV9; AllianceGenome:HGNC:12295
Gene type: other
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: V2; TRGC1; TCRGV9
Summary: Predicted to be involved in adaptive immune response and innate immune response. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: 7p14.1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (38317017..38317492, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (38473942..38474418, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (38356618..38357093, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High TRGV 9 Subfamily Expression Marks an Improved Overall Survival in Patients With Acute Myeloid Leukemia.
Title: High TRGV 9 Subfamily Expression Marks an Improved Overall Survival in Patients With Acute Myeloid Leukemia.
Large scale expansion of Vgamma9Vdelta2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS "TCR gamma/delta+ T cell isolation kit".
Title: Large scale expansion of Vgamma9Vdelta2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS "TCR gamma/delta+ T cell isolation kit".
support the concept of Vgamma9Vdelta2 T cells as sensors of a dysregulated isoprenoid metabolism
Title: Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells.
T cell in vitro stimulation analyses provide evidence that the CDR3 region of the Vgamma9Vdelta2 T cell receptor is involved in the recognition of the phosphorylated nonpetidic microbial metabolite, isopentenyl pyrophosphate.
Title: Functional and structural similarity of V gamma 9V delta 2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria.
Vgamma9Vdelta2 T cells contribute to the natural immune surveillance against colon cancers
Title: V gamma 9V delta 2 T cell response to colon carcinoma cells.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D7S2865 (e-PCR)
- UniSTS:82071

TCRG (e-PCR), detects polymorphism
- UniSTS:9391

GDB:385545 (e-PCR)
- UniSTS:157136

Other Names

T-cell receptor, gamma, variable region V9

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MHC protein binding	NAS Non-traceable Author Statement more info	PubMed
enables peptide antigen binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of T cell receptor complex	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.