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    Slc39a11 solute carrier family 39 (metal ion transporter), member 11 [ Mus musculus (house mouse) ]

    Gene ID: 69806, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc39a11provided by MGI
    Official Full Name
    solute carrier family 39 (metal ion transporter), member 11provided by MGI
    Primary source
    MGI:MGI:1917056
    See related
    Ensembl:ENSMUSG00000041654 AllianceGenome:MGI:1917056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZIP-11; 1810074D23Rik
    Summary
    Enables copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Involved in zinc ion import across plasma membrane. Located in Golgi apparatus; nucleus; and plasma membrane. Orthologous to human SLC39A11 (solute carrier family 39 member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in stomach adult (RPKM 17.8), colon adult (RPKM 17.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc39a11 in Genome Data Viewer
    Location:
    11 E2; 11 78.74 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113135677..113541050, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113244851..113650200, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732490B19 gene Neighboring gene predicted gene, 39505 Neighboring gene VISTA enhancer mm1526 Neighboring gene STARR-seq mESC enhancer starr_31081 Neighboring gene predicted gene, 30844 Neighboring gene predicted gene, 51927 Neighboring gene predicted gene, 51926 Neighboring gene predicted gene, 42094 Neighboring gene STARR-seq mESC enhancer starr_31085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113331428-113331537 Neighboring gene predicted gene, 51928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113427091-113427274 Neighboring gene STARR-seq mESC enhancer starr_31093 Neighboring gene STARR-seq mESC enhancer starr_31094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113473355-113473542 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113473648-113473949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113475868-113476055 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113478982-113479282 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene somatostatin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene STARR-seq mESC enhancer starr_31100 Neighboring gene STARR-seq mESC enhancer starr_31103 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. Martin AB, et al. J Nutr, 2013 Dec. PMID 24089422, Free PMC Article
    2. Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation. Kelleher SL, et al. J Cell Physiol, 2012 Apr. PMID 21702047, Free PMC Article
    3. Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter. Yu Y, et al. J Nutr Biochem, 2013 Oct. PMID 23643525
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc transporter ZIP11
    Names
    solute carrier family 39 member 11
    zrt- and Irt-like protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166503.1 → NP_001159975.1  zinc transporter ZIP11 isoform 1

      See identical proteins and their annotated locations for NP_001159975.1

      Status: VALIDATED

      Source sequence(s)
      AK036999, AK049368, BY299357
      Consensus CDS
      CCDS48975.1
      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Related
      ENSMUSP00000102244.4, ENSMUST00000106633.10
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    2. NM_001362937.1 → NP_001349866.1  zinc transporter ZIP11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL604025
      Conserved Domains (1) summary
      COG0428
      Location:80 → 416
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    3. NM_001362938.1 → NP_001349867.1  zinc transporter ZIP11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL604025
      Consensus CDS
      CCDS88280.1
      Related
      ENSMUSP00000037331.10, ENSMUST00000042657.16
      Conserved Domains (1) summary
      COG0428
      Location:6 → 370
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    4. NM_001362939.1 → NP_001349868.1  zinc transporter ZIP11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL603706, AL604025
      Consensus CDS
      CCDS48975.1
      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    5. NM_001362940.1 → NP_001349869.1  zinc transporter ZIP11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL604025
      Consensus CDS
      CCDS48975.1
      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    6. NM_001362941.1 → NP_001349870.1  zinc transporter ZIP11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL604025
      Consensus CDS
      CCDS36363.1
      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    7. NM_001362942.1 → NP_001349871.1  zinc transporter ZIP11 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL603706, AL604025
      Conserved Domains (1) summary
      COG0428
      Location:6 → 329
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    8. NM_001362943.1 → NP_001349872.1  zinc transporter ZIP11 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL603706, AL604025
      Conserved Domains (1) summary
      COG0428
      Location:1 → 292
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    9. NM_001362944.1 → NP_001349873.1  zinc transporter ZIP11 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL596104, AL603705, AL604025
      Conserved Domains (1) summary
      COG0428
      Location:6 → 285
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    10. NM_027216.5 → NP_081492.4  zinc transporter ZIP11 isoform 2

      See identical proteins and their annotated locations for NP_081492.4

      Status: VALIDATED

      Source sequence(s)
      AK036999, BY299357
      Consensus CDS
      CCDS36363.1
      UniProtKB/Swiss-Prot
      Q8BWY7
      Related
      ENSMUSP00000071469.4, ENSMUST00000071539.10
      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      113135677..113541050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246287.2 → XP_030102147.1  zinc transporter ZIP11 isoform X4

      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    2. XM_030246281.2 → XP_030102141.1  zinc transporter ZIP11 isoform X3

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    3. XM_011249239.4 → XP_011247541.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247541.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    4. XM_030246286.2 → XP_030102146.1  zinc transporter ZIP11 isoform X4

      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    5. XM_011249237.4 → XP_011247539.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247539.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    6. XM_030246284.2 → XP_030102144.1  zinc transporter ZIP11 isoform X4

      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    7. XM_030246280.2 → XP_030102140.1  zinc transporter ZIP11 isoform X3

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    8. XM_011249236.4 → XP_011247538.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247538.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    9. XM_030246283.2 → XP_030102143.1  zinc transporter ZIP11 isoform X4

      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    10. XM_011249231.3 → XP_011247533.1  zinc transporter ZIP11 isoform X3

      See identical proteins and their annotated locations for XP_011247533.1

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    11. XM_011249235.4 → XP_011247537.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247537.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    12. XM_036156969.1 → XP_036012862.1  zinc transporter ZIP11 isoform X3

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    13. XM_017314742.3 → XP_017170231.1  zinc transporter ZIP11 isoform X2

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    14. XM_036156968.1 → XP_036012861.1  zinc transporter ZIP11 isoform X3

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    15. XM_036156967.1 → XP_036012860.1  zinc transporter ZIP11 isoform X3

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    16. XM_036156966.1 → XP_036012859.1  zinc transporter ZIP11 isoform X2

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    17. XM_030246288.1 → XP_030102148.1  zinc transporter ZIP11 isoform X5

      Conserved Domains (1) summary
      COG0428
      Location:6 → 370
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    18. XM_011249230.1 → XP_011247532.1  zinc transporter ZIP11 isoform X1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 359
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    19. XM_011249233.1 → XP_011247535.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247535.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    20. XM_011249234.4 → XP_011247536.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247536.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    21. XM_011249240.4 → XP_011247542.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247542.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    22. XM_011249238.4 → XP_011247540.1  zinc transporter ZIP11 isoform X2

      See identical proteins and their annotated locations for XP_011247540.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 366
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    23. XM_030246282.2 → XP_030102142.1  zinc transporter ZIP11 isoform X3

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    24. XM_030246285.2 → XP_030102145.1  zinc transporter ZIP11 isoform X4

      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    25. XM_006534130.4 → XP_006534193.1  zinc transporter ZIP11 isoform X3

      See identical proteins and their annotated locations for XP_006534193.1

      UniProtKB/Swiss-Prot
      Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWY7.1 GenPept UniProtKB/Swiss-Prot:Q8BWY7

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