NLRP2 NLR family pyrin domain containing 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: NLRP2
Gene description: NLR family pyrin domain containing 2
See related: Ensembl:ENSMMUG00000003115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: NALP2
Orthologs: human all
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Genomic context

Location:: chromosome: 19

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	19	NC_041772.1 (54699186..54725219)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	19	NC_027911.1 (50174032..50208131)

Chromosome 19 - NC_041772.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 2

Names: NACHT, leucine rich repeat and PYD containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114352.1 → NP_001107824.1 NACHT, LRR and PYD domains-containing protein 2

See identical proteins and their annotated locations for NP_001107824.1

Status: PROVISIONAL

Source sequence(s)

EU344967

UniProtKB/TrEMBL

B0FPF0, F7H5S8

Related

ENSMMUP00000031436.3, ENSMMUT00000038336.3

Conserved Domains (5) summary

smart00382
Location:208 → 356

AAA; ATPases associated with a variety of cellular activities

cd00116
Location:790 → 1042

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:11 → 94

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:759 → 786

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:208 → 376

NACHT; NACHT domain