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    Atg10 autophagy related 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688555, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atg10provided by RGD
    Official Full Name
    autophagy related 10provided by RGD
    Primary source
    RGD:1587624
    See related
    EnsemblRapid:ENSRNOG00000016342 AllianceGenome:RGD:1587624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Atg12 conjugating enzyme activity. Predicted to be involved in ER overload response; macroautophagy; and protein modification by small protein conjugation. Predicted to act upstream of or within positive regulation of protein modification process and protein lipidation. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 28.6), Adrenal (RPKM 25.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atg10 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (23843695..24133459, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (22109304..22398313, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (19853546..20152918, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485712 Neighboring gene ATPase H+ transporting accessory protein 1 like Neighboring gene ribosomal protein S23 Neighboring gene uncharacterized LOC120100664 Neighboring gene uncharacterized LOC134485814 Neighboring gene uncharacterized LOC134485572

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. Shao Y, et al. Autophagy, 2007 Jan-Feb. PMID 16963840
    2. Inhibition of macroautophagy triggers apoptosis. Boya P, et al. Mol Cell Biol, 2005 Feb. PMID 15657430, Free PMC Article
    3. Regulation of autophagy by the inositol trisphosphate receptor. Criollo A, et al. Cell Death Differ, 2007 May. PMID 17256008
    4. METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1. Yu Z, et al. Biol Direct, 2024 Oct 16. PMID 39407279, Free PMC Article
    5. The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. Nemoto T, et al. J Biol Chem, 2003 Oct 10. PMID 12890687

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.
      Title: METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Atg12 conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Atg12 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Atg12 transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER overload response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification by small protein conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like-conjugating enzyme ATG10
    Names
    autophagy related 10 homolog
    autophagy-related protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109505.2 → NP_001102975.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      See identical proteins and their annotated locations for NP_001102975.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GLV9, A6I4P1
      Related
      ENSRNOP00000097036.2, ENSRNOT00000095702.2
      Conserved Domains (1) summary
      pfam03987
      Location:11 → 205
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    2. NM_001429163.1 → NP_001416092.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4P1

    3. NM_001429164.1 → NP_001416093.1  ubiquitin-like-conjugating enzyme ATG10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    4. NM_001429165.1 → NP_001416094.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      23843695..24133459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282566.1 → XP_063138636.1  ubiquitin-like-conjugating enzyme ATG10 isoform X5

    2. XM_063282568.1 → XP_063138638.1  ubiquitin-like-conjugating enzyme ATG10 isoform X8

    3. XM_063282567.1 → XP_063138637.1  ubiquitin-like-conjugating enzyme ATG10 isoform X7

    4. XM_063282569.1 → XP_063138639.1  ubiquitin-like-conjugating enzyme ATG10 isoform X9

    5. XM_039103148.2 → XP_038959076.1  ubiquitin-like-conjugating enzyme ATG10 isoform X1

      Related
      ENSRNOP00000104802.1, ENSRNOT00000127619.1
      Conserved Domains (1) summary
      pfam03987
      Location:154 → 313
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    6. XM_039103149.2 → XP_038959077.1  ubiquitin-like-conjugating enzyme ATG10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLV9, D4A9K6
      Related
      ENSRNOP00000021942.4, ENSRNOT00000021941.6
      Conserved Domains (1) summary
      pfam03987
      Location:31 → 225
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    7. XM_039103150.2 → XP_038959078.1  ubiquitin-like-conjugating enzyme ATG10 isoform X4

      Conserved Domains (1) summary
      pfam03987
      Location:11 → 205
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    8. XM_006231757.5 → XP_006231819.2  ubiquitin-like-conjugating enzyme ATG10 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLV9
      Related
      ENSRNOP00000106736.1, ENSRNOT00000142778.1
      Conserved Domains (1) summary
      pfam03987
      Location:30 → 224
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    9. XM_039103153.2 → XP_038959081.1  ubiquitin-like-conjugating enzyme ATG10 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GLV9
      Conserved Domains (1) summary
      pfam03987
      Location:22 → 181
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain

    10. XM_063282570.1 → XP_063138640.1  ubiquitin-like-conjugating enzyme ATG10 isoform X10

    11. XM_063282571.1 → XP_063138641.1  ubiquitin-like-conjugating enzyme ATG10 isoform X11

    RNA

    1. XR_010063662.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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