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    Etnppl ethanolamine-phosphate phospho-lyase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687071, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Etnpplprovided by RGD
    Official Full Name
    ethanolamine-phosphate phospho-lyaseprovided by RGD
    Primary source
    RGD:1590098
    See related
    EnsemblRapid:ENSRNOG00000045743 AllianceGenome:RGD:1590098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ethanolamine-phosphate phospho-lyase activity. Predicted to be located in mitochondrion. Orthologous to human ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 177.4), Liver (RPKM 176.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etnppl in Genome Data Viewer
    Location:
    2q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (221847210..221868827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (219173048..219194646)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (235738377..235760351)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene collagen type XXV alpha 1 chain Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC103691705 Neighboring gene uncharacterized LOC134485967 Neighboring gene oligosaccharyltransferase complex non-catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. Veiga-da-Cunha M, et al. J Biol Chem, 2012 Mar 2. PMID 22241472, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ethanolamine-phosphate phospho-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate phospho-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ethanolamine-phosphate phospho-lyase
    XP_003749444.1
    XP_038959776.1
    XP_038959777.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433244.1 → NP_001420173.1  ethanolamine-phosphate phospho-lyase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RNA

    1. NR_197345.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    2. NR_197346.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      221847210..221868827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003749396.6 → XP_003749444.1  ethanolamine-phosphate phospho-lyase isoform X1

      Related
      ENSRNOP00000065383.2, ENSRNOT00000074209.4
      Conserved Domains (2) summary
      cd00610
      Location:26 → 433
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:11 → 437
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    2. XM_039103848.2 → XP_038959776.1  ethanolamine-phosphate phospho-lyase isoform X2

      Conserved Domains (1) summary
      PRK06148
      Location:2 → 263
      PRK06148; hypothetical protein; Provisional

    3. XM_039103849.1 → XP_038959777.1  ethanolamine-phosphate phospho-lyase isoform X2

      Conserved Domains (1) summary
      PRK06148
      Location:2 → 263
      PRK06148; hypothetical protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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