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    Gpr155 G protein-coupled receptor 155 [ Mus musculus (house mouse) ]

    Gene ID: 68526, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gpr155provided by MGI
    Official Full Name
    G protein-coupled receptor 155provided by MGI
    Primary source
    MGI:MGI:1915776
    See related
    Ensembl:ENSMUSG00000041762 AllianceGenome:MGI:1915776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR22; DEPDC3; LYCHOS; 1110017O10Rik; F730029F15Rik
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and regulation of signal transduction. Predicted to be active in lysosomal membrane. Is expressed in several structures, including brain; genitourinary system; liver; spinal cord; and spleen. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 5.0), genital fat pad adult (RPKM 4.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr155 in Genome Data Viewer
    Location:
    2 C3; 2 43.59 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73171850..73216842, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73341506..73386521, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene secernin 3 Neighboring gene STARR-seq mESC enhancer starr_04837 Neighboring gene predicted gene 13709 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73224453-73224754 Neighboring gene predicted gene 13707 Neighboring gene STARR-positive B cell enhancer ABC_E2623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73288549-73288732 Neighboring gene WAS/WASL interacting protein family, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4467 Neighboring gene STARR-positive B cell enhancer ABC_E1245 Neighboring gene STARR-positive B cell enhancer ABC_E5934 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73324434-73324587 Neighboring gene STARR-positive B cell enhancer ABC_E2038 Neighboring gene predicted gene, 54162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR155: Gene organization, multiple mRNA splice variants and expression in mouse central nervous system. Trifonov S, et al. Biochem Biophys Res Commun, 2010 Jul 16. PMID 20537985
    2. Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains. Kobayashi M, et al. PLoS One, 2014. PMID 24789282, Free PMC Article
    3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • 1110017O10Rik, F730029F15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cholesterol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal cholesterol signaling protein
    Names
    integral membrane protein GPR155

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190297.2 → NP_001177226.1  lysosomal cholesterol signaling protein isoform 1

      See identical proteins and their annotated locations for NP_001177226.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL954713, AV115983, HM161763
      Consensus CDS
      CCDS50606.1
      UniProtKB/Swiss-Prot
      A2AWR2, A2AWR3, D7RXL9, D7RXM0, Q14BN5, Q80UC0, Q8R0W2
      Related
      ENSMUSP00000075788.6, ENSMUST00000076463.12
      Conserved Domains (2) summary
      cd04443
      Location:749 → 831
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein

    2. NM_001276443.1 → NP_001263372.1  lysosomal cholesterol signaling protein isoform 3

      See identical proteins and their annotated locations for NP_001263372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL954713, AV115983, HM161764
      UniProtKB/TrEMBL
      D7RXL9
      Conserved Domains (2) summary
      cl02442
      Location:749 → 776
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein

    3. NM_001276444.1 → NP_001263373.1  lysosomal cholesterol signaling protein isoform 4

      See identical proteins and their annotated locations for NP_001263373.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AL954713, AV115983, HM161766
      Consensus CDS
      CCDS71075.1
      UniProtKB/TrEMBL
      A2AWR2
      Related
      ENSMUSP00000107675.2, ENSMUST00000112044.8
      Conserved Domains (2) summary
      cd04443
      Location:721 → 803
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73171850..73216842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500106.3 → XP_006500169.1  lysosomal cholesterol signaling protein isoform X2

      See identical proteins and their annotated locations for XP_006500169.1

      UniProtKB/Swiss-Prot
      A2AWR2, A2AWR3, D7RXL9, D7RXM0, Q14BN5, Q80UC0, Q8R0W2
      Conserved Domains (2) summary
      cd04443
      Location:749 → 831
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein

    2. XM_006500104.3 → XP_006500167.1  lysosomal cholesterol signaling protein isoform X1

      See identical proteins and their annotated locations for XP_006500167.1

      Conserved Domains (2) summary
      cd04443
      Location:762 → 844
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:49 → 377
      Mem_trans; Membrane transport protein

    3. XM_006500105.3 → XP_006500168.1  lysosomal cholesterol signaling protein isoform X1

      See identical proteins and their annotated locations for XP_006500168.1

      Conserved Domains (2) summary
      cd04443
      Location:762 → 844
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:49 → 377
      Mem_trans; Membrane transport protein

    4. XM_006500107.4 → XP_006500170.1  lysosomal cholesterol signaling protein isoform X3

      Related
      ENSMUST00000048504.10
      Conserved Domains (2) summary
      cl22894
      Location:49 → 377
      Mem_trans; Membrane transport protein
      cl02442
      Location:762 → 789
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

    5. XM_006500108.5 → XP_006500171.1  lysosomal cholesterol signaling protein isoform X4

      Conserved Domains (2) summary
      cl22894
      Location:49 → 377
      Mem_trans; Membrane transport protein
      cl02442
      Location:762 → 790
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080707.1: Suppressed sequence

      Description
      NM_001080707.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AWR3.1 GenPept UniProtKB/Swiss-Prot:A2AWR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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