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    Prss2l1 protease, serine, 2 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683849, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Prss2l1provided by RGD
    Official Full Name
    protease, serine, 2 like 1provided by RGD
    Primary source
    RGD:1597830
    See related
    EnsemblRapid:ENSRNOG00000050493 AllianceGenome:RGD:1597830
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS1 (serine protease 1); PRSS2 (serine protease 2); and PRSS3 (serine protease 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 1096.6) and Liver (RPKM 397.5) See more
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    Genomic context

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    See Prss2l1 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (71310998..71314666)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70344338..70348069)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70755780..70759478)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protease, serine, 2, pseudogene 1 Neighboring gene anionic trypsin-2-like Neighboring gene serine protease 1 Neighboring gene T-cell receptor beta-1 chain C region-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anionic trypsin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      71310998..71314666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003749732.6 → XP_003749780.1  anionic trypsin-2

      See identical proteins and their annotated locations for XP_003749780.1

      UniProtKB/TrEMBL
      A6IF27, A6IF30, W4VSR6
      Related
      ENSRNOP00000043620.4, ENSRNOT00000043527.6
      Conserved Domains (2) summary
      smart00020
      Location:23 → 239
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24 → 242
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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