Ino80 INO80 complex subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ino80provided by MGI
Official Full Name: INO80 complex subunitprovided by MGI
Primary source: MGI:MGI:1915392
See related: Ensembl:ENSMUSG00000034154 AllianceGenome:MGI:1915392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Inoc1; 2310079N15Rik; 4632409L19Rik
Summary: Predicted to enable several functions, including ATP hydrolysis activity; alpha-tubulin binding activity; and histone binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in cytosol and nuclear body. Predicted to be part of Ino80 complex. Is expressed in several structures, including ectoderm; genitourinary system; liver; muscle tissue; and primitive endoderm. Orthologous to human INO80 (INO80 complex ATPase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 5.8), limb E14.5 (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.97 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119203523..119308168, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119373042..119478685, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.
Title: INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.
INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells.
Title: INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells.
Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
Title: Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy.
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.
Title: Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.
Data show that deletion of the Ino80 in vascular endothelial cells prevents ventricular compaction in the developing heart.
Title: Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
Title: Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.
Ino80 represses Bmp4 expression during embryonic stem cell differentiation.
Title: Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.
The loss of INO80 resulted in an arrest during meiosis associated with a failure to repair DNA damage during meiotic recombination
Title: The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis.
INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Title: Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis.
data reveal an essential role for INO80 in the expression of the pluripotency network and illustrate the coordination among chromatin remodeler, transcription factor, and histone-modifying enzyme in the regulation of the pluripotent state.
Title: INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in UV-damage excision repair	IEA Inferred from Electronic Annotation more info
involved_in UV-damage excision repair	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear cell cycle DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nuclear cell cycle DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ino80 complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chromatin-remodeling ATPase INO80

Names: DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; INO80 complex subunit A; putative DNA helicase INO80 complex homolog 1; yeast INO80-like protein

NP_080850.2

EC 3.6.4.12

XP_036018407.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026574.4 → NP_080850.2 chromatin-remodeling ATPase INO80

See identical proteins and their annotated locations for NP_080850.2

Status: VALIDATED

Source sequence(s)

AL844862, AL929318

Consensus CDS

CCDS16602.1

UniProtKB/Swiss-Prot

A2AQP8, Q6P7V0, Q6PCP1, Q6ZPV2, Q8C9T7

Related

ENSMUSP00000051845.8, ENSMUST00000049920.14

Conserved Domains (3) summary

COG0553
Location:350 → 1262

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18002
Location:520 → 748

DEXQc_INO80; DEAQ-box helicase domain of INO80

pfam13892
Location:275 → 404

DBINO; DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

119203523..119308168 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162514.1 → XP_036018407.1 chromatin-remodeling ATPase INO80 isoform X1

UniProtKB/Swiss-Prot

A2AQP8, Q6P7V0, Q6PCP1, Q6ZPV2, Q8C9T7

Conserved Domains (3) summary

COG0553
Location:350 → 1262

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18002
Location:520 → 748

DEXQc_INO80; DEAQ-box helicase domain of INO80

pfam13892
Location:275 → 404

DBINO; DNA-binding domain