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    Krt87 keratin 87 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681126, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Krt87provided by RGD
    Official Full Name
    keratin 87provided by RGD
    Primary source
    RGD:1583565
    See related
    EnsemblRapid:ENSRNOG00000032859 AllianceGenome:RGD:1583565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Krt83
    Summary
    Predicted to be involved in aging and hair cycle. Predicted to be located in keratin filament. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 5 and monilethrix. Orthologous to human KRT83 (keratin 83). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 24.6) and Uterus (RPKM 5.7) See more
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    Genomic context

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    See Krt87 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134426567..134433740, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132547388..132555005, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143078996..143085833, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25-like Neighboring gene keratin 7 Neighboring gene keratin 88 Neighboring gene keratin 81

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. Nanashima N, et al. J Biol Chem, 2008 Jun 13. PMID 18420582
    2. Hair greying is associated with active hair growth. Choi HI, et al. Br J Dermatol, 2011 Dec. PMID 21916889
    3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pieragostino D, et al. Mol Biosyst, 2013 Jun. PMID 23580065
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in hair cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular Hb3
    Names
    keratin 83
    keratin 83, type II
    keratin complex 2, basic, gene 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101675.2 → NP_001095145.1  keratin, type II cuticular Hb3

      See identical proteins and their annotated locations for NP_001095145.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A9T4, A7M746, D4ABK6
      Related
      ENSRNOP00000029805.3, ENSRNOT00000031257.6
      Conserved Domains (3) summary
      pfam00038
      Location:110 → 421
      Filament; Intermediate filament protein
      pfam16208
      Location:4 → 107
      Keratin_2_head; Keratin type II head
      cl23720
      Location:320 → 388
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134426567..134433740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264250.1 → XP_063120320.1  keratin, type II cuticular Hb3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSZ3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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