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    Snrpg small nuclear ribonucleoprotein polypeptide G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681031, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Snrpgprovided by RGD
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Gprovided by RGD
    Primary source
    RGD:1584713
    See related
    EnsemblRapid:ENSRNOG00000016507 AllianceGenome:RGD:1584713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables U1 snRNP binding activity. Predicted to be involved in spliceosomal snRNP assembly. Part of U1 snRNP. Orthologous to human SNRPG (small nuclear ribonucleoprotein polypeptide G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 904.5), Spleen (RPKM 666.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrpg in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120369676..120377263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118812278..118819827)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118167267..118174846)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350725 Neighboring gene family with sequence similarity 136, member A Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene prenylcysteine oxidase 1 Neighboring gene transfer RNA glycine (anticodon CCC) 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. Lin SJ, et al. J Proteomics, 2013 Dec 6. PMID 24080422
    2. Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis. Nováková Z, et al. Electrophoresis, 2006 Apr. PMID 16502463
    3. Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. Leung AK, et al. Nature, 2011 May 26. PMID 21516107, Free PMC Article
    4. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. Pillai RS, et al. EMBO J, 2001 Oct 1. PMID 11574479, Free PMC Article
    5. Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. Kondo Y, et al. Elife, 2015 Jan 2. PMID 25555158, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188855

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U7 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small nuclear ribonucleoprotein G
    NP_001128557.1
    XP_063142751.1
    XP_063142752.1
    XP_063142753.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135085.1 → NP_001128557.1  small nuclear ribonucleoprotein G

      See identical proteins and their annotated locations for NP_001128557.1

      Status: VALIDATED

      Source sequence(s)
      BC168750, BI285268
      UniProtKB/TrEMBL
      A0A8I5ZRW0, A6IAV9, B5DEP7, F7F7T6
      Related
      ENSRNOP00000022367.2, ENSRNOT00000022367.5
      Conserved Domains (1) summary
      cd01719
      Location:5 → 74
      Sm_G; Sm protein G

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      120369676..120377263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286683.1 → XP_063142753.1  small nuclear ribonucleoprotein G isoform X2

      UniProtKB/TrEMBL
      A6IAW0

    2. XM_063286681.1 → XP_063142751.1  small nuclear ribonucleoprotein G isoform X1

      UniProtKB/TrEMBL
      A6IAW1

    3. XM_063286682.1 → XP_063142752.1  small nuclear ribonucleoprotein G isoform X1

      UniProtKB/TrEMBL
      A6IAW1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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