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    Hoga1 4-hydroxy-2-oxoglutarate aldolase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67432, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hoga1provided by MGI
    Official Full Name
    4-hydroxy-2-oxoglutarate aldolase 1provided by MGI
    Primary source
    MGI:MGI:1914682
    See related
    Ensembl:ENSMUSG00000025176 AllianceGenome:MGI:1914682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npl2; Dhdpsl; 0610010D20Rik
    Summary
    Predicted to enable (R,S)-4-hydroxy-2-oxoglutarate aldolase activity; N-acetylneuraminate lyase activity; and protein homodimerization activity. Predicted to be involved in carboxylic acid metabolic process. Located in mitochondrion. Used to study primary hyperoxaluria. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 3. Orthologous to human HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 87.7), kidney adult (RPKM 62.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hoga1 in Genome Data Viewer
    Location:
    19 C3; 19 35.67 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42033998..42060128)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42045559..42071689)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_46168 Neighboring gene STARR-seq mESC enhancer starr_46171 Neighboring gene ankyrin repeat domain 2 Neighboring gene RIKEN cDNA 4933411K16 gene Neighboring gene MORN repeat containing 4 Neighboring gene STARR-seq mESC enhancer starr_46172 Neighboring gene STARR-positive B cell enhancer ABC_E781 Neighboring gene STARR-seq mESC enhancer starr_46173 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3. Li X, et al. Biochim Biophys Acta, 2015 Dec. PMID 26428388, Free PMC Article
    2. In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of primary hyperoxaluria. Martinez-Turrillas R, et al. Mol Ther Methods Clin Dev, 2022 Jun 9. PMID 35402636, Free PMC Article
    3. Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice. Srivastava U, et al. Arterioscler Thromb Vasc Biol, 2012 Oct. PMID 22837474, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables N-acetylneuraminate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 4-hydroxyproline catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 4-hydroxyproline catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glyoxylate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glyoxylate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxalate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxalate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial
    Names
    DHDPS-like protein
    N-acetylneuraminate pyruvate lyase 2 (putative)
    dihydrodipicolinate synthase-like, mitochondrial
    probable 2-keto-4-hydroxyglutarate aldolase
    probable KHG-aldolase
    NP_080428.1
    XP_030106914.1
    XP_030106915.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026152.2 → NP_080428.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080428.1

      Status: VALIDATED

      Source sequence(s)
      AC133503, AK002457
      Consensus CDS
      CCDS29820.1
      UniProtKB/Swiss-Prot
      Q91W74, Q9CY60, Q9DCU9
      Related
      ENSMUSP00000080414.5, ENSMUST00000081714.5
      Conserved Domains (1) summary
      cd00408
      Location:32 → 312
      DHDPS-like; Dihydrodipicolinate synthase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      42033998..42060128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251054.1 → XP_030106914.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd00408
      Location:6 → 198
      DHDPS-like; Dihydrodipicolinate synthase family

    2. XM_030251055.1 → XP_030106915.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd00408
      Location:6 → 198
      DHDPS-like; Dihydrodipicolinate synthase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCU9.1 GenPept UniProtKB/Swiss-Prot:Q9DCU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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