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    Plekho1 pleckstrin homology domain containing, family O member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67220, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plekho1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family O member 1provided by MGI
    Primary source
    MGI:MGI:1914470
    See related
    Ensembl:ENSMUSG00000015745 AllianceGenome:MGI:1914470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jza2; Ckip1; CKIP-1; JZA-20; 2810052M02Rik
    Summary
    Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 51.0), CNS E11.5 (RPKM 47.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekho1 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95896110..95903258, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95988809..95999355, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ferritin light chain 2 pseudogene Neighboring gene predicted gene 9054 Neighboring gene vacuolar protein sorting 45 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95836233-95836533 Neighboring gene STARR-positive B cell enhancer ABC_E2674 Neighboring gene predicted gene, 54210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95861936-95862045 Neighboring gene STARR-positive B cell enhancer ABC_E6079 Neighboring gene predicted gene, 30044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis. He X, et al. EBioMedicine, 2019 Mar. PMID 30824383, Free PMC Article
    2. Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway. Dong B, et al. Mol Biomed, 2024 Jun 14. PMID 38871861, Free PMC Article
    3. CKIP-1 knockout offsets osteoporosis induced by simulated microgravity. Zhang X, et al. Prog Biophys Mol Biol, 2016 Nov. PMID 27666961
    4. CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα. Li D, et al. J Mol Cell Biol, 2014 Oct. PMID 25240053
    5. Integrated analysis of genomics and proteomics reveals that CKIP-1 is a novel macrophage migration regulator. Zhang L, et al. Biochem Biophys Res Commun, 2013 Jul 5. PMID 23747421

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway.
      Title: Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway.
    2. CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.
      Title: CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.
    3. [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
      Title: [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
    4. The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
      Title: The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
    5. Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization.
      Title: Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization.
    6. CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
      Title: CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
    7. CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells.
      Title: CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells.
    8. 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.
      Title: 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.
    9. Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells.
      Title: Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells.
    10. CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway.
      Title: CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151380

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lamellipodium morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in muscle cell projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in muscle cell projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family O member 1
    Names
    CK2 interacting protein 1
    Jun zipper-associated 2
    PH domain-containing family O member 1
    TNF intracellular domain-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418048.1 → NP_001404977.1  pleckstrin homology domain-containing family O member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092855

    2. NM_023320.3 → NP_075809.1  pleckstrin homology domain-containing family O member 1 isoform 1

      See identical proteins and their annotated locations for NP_075809.1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      Consensus CDS
      CCDS17627.1
      UniProtKB/Swiss-Prot
      Q9CXH2, Q9JIY0
      UniProtKB/TrEMBL
      F6XQM2
      Related
      ENSMUSP00000015889.4, ENSMUST00000015889.10
      Conserved Domains (2) summary
      cd13317
      Location:17 → 126
      PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
      pfam00169
      Location:25 → 130
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95896110..95903258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240206.2 → XP_011238508.1  pleckstrin homology domain-containing family O member 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIY0.1 GenPept UniProtKB/Swiss-Prot:Q9JIY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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