Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smarca2provided by MGI
Official Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by MGI
Primary source: MGI:MGI:99603
See related: Ensembl:ENSMUSG00000024921 AllianceGenome:MGI:99603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: brm; Snf2l2; brahma; SNF2alpha; 2610209L14Rik
Summary: Predicted to enable several functions, including chromatin binding activity; nucleosome array spacer activity; and transcription coactivator activity. Acts upstream of or within aortic smooth muscle cell differentiation; hematopoietic stem cell homeostasis; and negative regulation of fibroblast proliferation. Located in nucleus. Part of nBAF complex and npBAF complex. Is expressed in several structures, including early conceptus; genitourinary system; heart; telencephalon; and vitelline artery. Human ortholog(s) of this gene implicated in Nicolaides-Baraitser syndrome and blepharophimosis-impaired intellectual development syndrome. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 20.4), lung adult (RPKM 19.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 21.17 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (26582578..26755721)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (26605073..26778321)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The impact of SWI/SNF and NuRD inactivation on gene expression is tightly coupled with levels of RNA polymerase II occupancy at promoters.
Title: The impact of SWI/SNF and NuRD inactivation on gene expression is tightly coupled with levels of RNA polymerase II occupancy at promoters.
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Title: Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects.
Title: Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects.
Brahma safeguards canalization of cardiac mesoderm differentiation.
Title: Brahma safeguards canalization of cardiac mesoderm differentiation.
In both mouse keratinocytes and HaCaT cells, Brm deficiency led to an increased cell population growth following ultraviolet radiation (UVR) exposure compared to cells with normal levels of Brm. The loss of Brm in keratinocytes exposed to UVR enables them to resume proliferation while harboring DNA photolesions, leading to an increased fixation of mutations and, consequently, increased carcinogenesis.
Title: Brahma deficiency in keratinocytes promotes UV carcinogenesis by accelerating the escape from cell cycle arrest and the formation of DNA photolesions.
PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.
Title: PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.
BRG1/BRM and c-MYC have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene in cancer.
Title: BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.
SWI/SNF chromatin remodeler subunits Brg1 and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model.
Title: Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.
these findings described a role for BRG1 and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte
Title: BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.
BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.
Title: SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19Mit99 (e-PCR), detects polymorphism
- UniSTS:128435

Smarca2 (e-PCR), detects polymorphism
- UniSTS:516566

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aortic smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleosome assembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of GBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	ISO Inferred from Sequence Orthology more info
part_of SWI/SNF complex	TAS Traceable Author Statement more info	PubMed
part_of SWI/SNF superfamily-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of bBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of brahma complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of nBAF complex	IDA Inferred from Direct Assay more info	PubMed
part_of nBAF complex	NAS Non-traceable Author Statement more info	PubMed
part_of npBAF complex	IDA Inferred from Direct Assay more info	PubMed
part_of npBAF complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable global transcription activator SNF2L2

Names: ATP-dependent helicase SMARCA2; BAF190B; BRG1-associated factor 190B; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; protein brahma homolog; subunit of the SWI/SNF chromatin remodeling complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347439.2 → NP_001334368.1 probable global transcription activator SNF2L2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC118472

Consensus CDS

CCDS84428.1

UniProtKB/TrEMBL

H3BK47

Conserved Domains (2) summary

cd05516
Location:86 → 192

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:37 → 99

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001405130.1 → NP_001392059.1 probable global transcription activator SNF2L2 isoform 1

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

F2Z4A9
NM_001405131.1 → NP_001392060.1 probable global transcription activator SNF2L2 isoform 1

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

F2Z4A9
NM_001405132.1 → NP_001392061.1 probable global transcription activator SNF2L2 isoform 1

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

F2Z4A9
NM_001405133.1 → NP_001392062.1 probable global transcription activator SNF2L2 isoform 4

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

H3BLH0
NM_001405134.1 → NP_001392063.1 probable global transcription activator SNF2L2 isoform 4

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

H3BLH0
NM_001405135.1 → NP_001392064.1 probable global transcription activator SNF2L2 isoform 4

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

H3BLH0

Related

ENSMUSP00000135784.2, ENSMUST00000176030.8
NM_001405136.1 → NP_001392065.1 probable global transcription activator SNF2L2 isoform 4

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

UniProtKB/TrEMBL

H3BLH0
NM_011416.3 → NP_035546.2 probable global transcription activator SNF2L2 isoform 1

See identical proteins and their annotated locations for NP_035546.2

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

Consensus CDS

CCDS29720.1

UniProtKB/Swiss-Prot

Q6DIC0

UniProtKB/TrEMBL

F2Z4A9

Related

ENSMUSP00000025862.8, ENSMUST00000025862.15

Conserved Domains (9) summary

cd05516
Location:1393 → 1499

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00573
Location:447 → 519

HSA; domain in helicases and associated with SANT domains

PLN03142
Location:731 → 1213

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

PHA03378
Location:74 → 393

PHA03378; EBNA-3B; Provisional

cd18063
Location:712 → 962

DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2

pfam07533
Location:601 → 643

BRK; BRK domain

pfam08880
Location:173 → 207

QLQ

pfam14619
Location:1271 → 1337

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl02556
Location:1344 → 1439

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_026003.3 → NP_080279.1 probable global transcription activator SNF2L2 isoform 2

See identical proteins and their annotated locations for NP_080279.1

Status: VALIDATED

Source sequence(s)

AC118472

Consensus CDS

CCDS37945.1

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000108256.3, ENSMUST00000112637.10

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

RNA

NR_175915.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC118249, AC118472
NR_175916.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC118249, AC118472

Related

ENSMUST00000099537.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

26582578..26755721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527286.3 → XP_006527349.1 probable global transcription activator SNF2L2 isoform X2

UniProtKB/Swiss-Prot

Q6DIC0

Conserved Domains (9) summary

cd05516
Location:1317 → 1441

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

PLN03142
Location:655 → 1137

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

PHA03378
Location:6 → 317

PHA03378; EBNA-3B; Provisional

cd18063
Location:636 → 886

DEXHc_SMARCA2; DEXH-box helicase domain of SMARCA2

pfam07529
Location:372 → 442

HSA

pfam07533
Location:524 → 565

BRK; BRK domain

pfam08880
Location:97 → 131

QLQ

pfam14619
Location:1196 → 1261

SnAC; Snf2-ATP coupling, chromatin remodelling complex

cl02556
Location:1268 → 1354

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030251047.1 → XP_030106907.1 probable global transcription activator SNF2L2 isoform X5

UniProtKB/TrEMBL

H3BK47

Conserved Domains (2) summary

cd05516
Location:86 → 192

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:37 → 99

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_017318278.2 → XP_017173767.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000135412.2, ENSMUST00000175791.9

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030251051.1 → XP_030106911.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000146924.2, ENSMUST00000208751.2

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006527288.3 → XP_006527351.1 probable global transcription activator SNF2L2 isoform X5

See identical proteins and their annotated locations for XP_006527351.1

UniProtKB/TrEMBL

H3BK47

Related

ENSMUSP00000146379.2, ENSMUST00000207118.2

Conserved Domains (2) summary

cd05516
Location:86 → 192

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:37 → 99

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030251046.1 → XP_030106906.1 probable global transcription activator SNF2L2 isoform X5

UniProtKB/TrEMBL

H3BK47

Related

ENSMUSP00000146994.2, ENSMUST00000209085.2

Conserved Domains (2) summary

cd05516
Location:86 → 192

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:37 → 99

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006527289.4 → XP_006527352.1 probable global transcription activator SNF2L2 isoform X5

See identical proteins and their annotated locations for XP_006527352.1

UniProtKB/TrEMBL

H3BK47

Related

ENSMUSP00000135248.2, ENSMUST00000176475.9

Conserved Domains (2) summary

cd05516
Location:86 → 192

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:37 → 99

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030251045.2 → XP_030106905.1 probable global transcription activator SNF2L2 isoform X4

UniProtKB/TrEMBL

A0A140LHP6

Related

ENSMUSP00000146493.2, ENSMUST00000207054.2

Conserved Domains (2) summary

cd05516
Location:88 → 194

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:39 → 101

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_006527291.4 → XP_006527354.1 probable global transcription activator SNF2L2 isoform X6

See identical proteins and their annotated locations for XP_006527354.1

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000146890.2, ENSMUST00000208589.2

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030251049.2 → XP_030106909.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000134914.2, ENSMUST00000176698.9

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_036161667.1 → XP_036017560.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000134995.3, ENSMUST00000177252.9

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_030251050.2 → XP_030106910.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_017318277.3 → XP_017173766.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Related

ENSMUSP00000146875.2, ENSMUST00000208091.2

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_017318276.3 → XP_017173765.1 probable global transcription activator SNF2L2 isoform X6

UniProtKB/TrEMBL

Q9D007

Conserved Domains (2) summary

cd05516
Location:46 → 152

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

cl02556
Location:2 → 59

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.