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    ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit [ Danio rerio (zebrafish) ]

    Gene ID: 664754, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ezh1provided by ZNC
    Official Full Name
    enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050114-1
    See related
    Ensembl:ENSDARG00000037894 AllianceGenome:ZFIN:ZDB-GENE-050114-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136829; si:ch211-250i3.1
    Summary
    Predicted to enable chromatin binding activity and histone H3K27 methyltransferase activity. Acts upstream of or within arterial endothelial cell fate commitment. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; eye; gonad; gut; and pectoral fin bud. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ezh1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36859586..36892368)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36717740..36750507)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2 Neighboring gene multidrug resistance-associated protein 1-like Neighboring gene receptor (G protein-coupled) activity modifying protein 2 Neighboring gene contactin associated protein 1 Neighboring gene uncharacterized LOC137490132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The ezh2(sa1199) mutant zebrafish display no distinct phenotype. San B, et al. PLoS One, 2019. PMID 30677064, Free PMC Article
    2. Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development. Völkel P, et al. Sci Rep, 2019 Mar 13. PMID 30867490, Free PMC Article
    3. Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development. Chrispijn ND, et al. PLoS One, 2018. PMID 29985950, Free PMC Article
    4. Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Crippa S, et al. Cardiovasc Res, 2016 May 1. PMID 26857418, Free PMC Article
    5. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Soto RA, et al. Stem Cell Reports, 2021 Jul 13. PMID 34143974, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2.
      Title: Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2.
    2. Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development.
      Title: Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC136829

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within arterial endothelial cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase EZH1
    Names
    enhancer of zeste homolog 1
    NP_001035072.2
    XP_005164197.1
    XP_009297915.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039983.2 → NP_001035072.2  histone-lysine N-methyltransferase EZH1

      Status: VALIDATED

      Source sequence(s)
      AL929523
      UniProtKB/TrEMBL
      A0A8M1N8R5, E7FFB7
      Related
      ENSDARP00000028564.8, ENSDART00000039170.8
      Conserved Domains (4) summary
      smart00317
      Location:622 → 743
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:476 → 736
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:447 → 489
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:45 → 73
      EZH2_WD-Binding; WD repeat binding protein EZH2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      36859586..36892368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299640.4 → XP_009297915.1  histone-lysine N-methyltransferase EZH1 isoform X1

      See identical proteins and their annotated locations for XP_009297915.1

      UniProtKB/TrEMBL
      A0A8M2BBL7
      Conserved Domains (4) summary
      smart00317
      Location:615 → 736
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:469 → 729
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:440 → 482
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:45 → 73
      EZH2_WD-Binding; WD repeat binding protein EZH2

    2. XM_005164140.5 → XP_005164197.1  histone-lysine N-methyltransferase EZH1 isoform X1

      See identical proteins and their annotated locations for XP_005164197.1

      UniProtKB/TrEMBL
      A0A8M2BBL7
      Related
      ENSDARP00000124899.1, ENSDART00000149659.2
      Conserved Domains (4) summary
      smart00317
      Location:615 → 736
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:469 → 729
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:440 → 482
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam11616
      Location:45 → 73
      EZH2_WD-Binding; WD repeat binding protein EZH2
    Nucleotide Protein Strain
    Heading Accession and Version

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