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    Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66015, updated on 2-Nov-2024

    Summary

    Official Symbol
    Adamts4provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 4provided by RGD
    Primary source
    RGD:621242
    See related
    EnsemblRapid:ENSRNOG00000003538 AllianceGenome:RGD:621242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity; protease binding activity; and zinc ion binding activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular space and nuclear speck. Predicted to be active in extracellular matrix. Biomarker of degenerative disc disease and transient cerebral ischemia. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 40.7), Uterus (RPKM 12.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Adamts4 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86203011..86212500)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83670556..83680045)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89622996..89632485)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein A2 Neighboring gene Fc epsilon receptor Ig Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene protoporphyrinogen oxidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 4
    Names
    ADAM-TS 4
    ADAM-TS4
    ADAMTS-4
    Aggrecanase
    a disintegrin and metallopeptidase with thrombospondin motifs 4
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
    aggrecanase-1
    NP_076449.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023959.1NP_076449.1  A disintegrin and metalloproteinase with thrombospondin motifs 4

      Status: VALIDATED

      Source sequence(s)
      AB042271, AB042272, AB042273, CB614460, JAXUCZ010000013
      UniProtKB/TrEMBL
      D4A0C5
      Related
      ENSRNOP00000004713.6, ENSRNOT00000004713.9
      Conserved Domains (6) summary
      smart00209
      Location:545589
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:232439
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:232442
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:92195
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:701816
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:452523
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86203011..86212500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)