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    SLC8A1 solute carrier family 8 member A1 [ Homo sapiens (human) ]

    Gene ID: 6546, updated on 12-Nov-2024

    Summary

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    Official Symbol
    SLC8A1provided by HGNC
    Official Full Name
    solute carrier family 8 member A1provided by HGNC
    Primary source
    HGNC:HGNC:11068
    See related
    Ensembl:ENSG00000183023 MIM:182305; AllianceGenome:HGNC:11068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCX1
    Summary
    In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
    Expression
    Broad expression in heart (RPKM 35.6), endometrium (RPKM 9.9) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC8A1 in Genome Data Viewer
    Location:
    2p22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (40097270..40512435, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (40106262..40521419, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (40324410..40739575, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268436 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:40128919-40130118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:40147641-40148300 Neighboring gene zinc finger protein 19 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:40165083-40166282 Neighboring gene SLC8A1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:40240930-40241498 Neighboring gene Sharpr-MPRA regulatory region 6978 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:40371191-40371761 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:40437586-40438180 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:40469400-40469950 Neighboring gene NANOG hESC enhancer GRCh37_chr2:40545966-40546467 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene Sharpr-MPRA regulatory region 14225 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:40661639-40662838 Neighboring gene uncharacterized LOC101929667 Neighboring gene uncharacterized LOC105374473 Neighboring gene uncharacterized LOC105374475

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key Proteins Associated with the Disease.
      Title: In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key Proteins Associated with the Disease.
    2. Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.
      Title: Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.
    3. LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
      Title: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
    4. Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.
      Title: Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.
    5. NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.
      Title: NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.
    6. Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.
      Title: Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.
    7. Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.
      Title: Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.
    8. NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/beta-catenin pathway.
      Title: NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.
    9. Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.
      Title: Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.
    10. circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.
      Title: circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (93)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.
    EBI GWAS Catalog
    A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.
    EBI GWAS Catalog
    A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
    EBI GWAS Catalog
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.
    EBI GWAS Catalog
    Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.
    EBI GWAS Catalog
    Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
    EBI GWAS Catalog
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    EBI GWAS Catalog
    Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37694, FLJ43417, MGC119581, DKFZp779F0871

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ankyrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:sodium antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium:sodium antiporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion export IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane import into cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell communication by electrical coupling involved in cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to caffeine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular sodium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane depolarization during cardiac muscle cell action potential TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of the force of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac conduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell communication by electrical coupling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of the force of heart contraction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of the force of heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in relaxation of cardiac muscle IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in relaxation of cardiac muscle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in relaxation of smooth muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular associated smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in T-tubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axon terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intercalated disc TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium/calcium exchanger 1
    Names
    Na(+)/Ca(2+)-exchange protein 1
    Na+/Ca++ exchanger
    Na+/Ca2+ exchanger
    solute carrier family 8 (sodium/calcium exchanger), member 1
    solute carrier family 8 member 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112800.4 → NP_001106271.1  sodium/calcium exchanger 1 isoform B precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS46265.1
      UniProtKB/Swiss-Prot
      P32418
      UniProtKB/TrEMBL
      Q4QQH3
      Related
      ENSP00000385678.3, ENST00000405901.7
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 968
      caca; sodium/calcium exchanger 1

    2. NM_001112801.3 → NP_001106272.1  sodium/calcium exchanger 1 isoform C precursor

      See identical proteins and their annotated locations for NP_001106272.1

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92742.1
      UniProtKB/Swiss-Prot
      P32418
      Related
      ENSP00000516142.1, ENST00000705604.1
      Conserved Domains (5) summary
      smart00237
      Location:537 → 627
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      TIGR00845
      Location:4 → 960
      caca; sodium/calcium exchanger 1
      pfam01699
      Location:787 → 951
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03160
      Location:406 → 496
      Calx-beta; Calx-beta domain
      pfam16494
      Location:254 → 384
      Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

    3. NM_001112802.2 → NP_001106273.1  sodium/calcium exchanger 1 isoform D precursor

      See identical proteins and their annotated locations for NP_001106273.1

      Status: VALIDATED

      Source sequence(s)
      AC007254, AK291696
      Consensus CDS
      CCDS46264.1
      UniProtKB/Swiss-Prot
      P32418
      Related
      ENSP00000385188.1, ENST00000402441.5
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 937
      caca; sodium/calcium exchanger 1

    4. NM_001252624.2 → NP_001239553.1  sodium/calcium exchanger 1 isoform E precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377
      Consensus CDS
      CCDS59430.1
      UniProtKB/Swiss-Prot
      P32418
      Related
      ENSP00000384908.2, ENST00000408028.6
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 965
      caca; sodium/calcium exchanger 1

    5. NM_001351483.2 → NP_001338412.1  sodium/calcium exchanger 1 isoform F precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92746.1
      UniProtKB/TrEMBL
      E9PB98
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 945
      caca; sodium/calcium exchanger 1

    6. NM_001351484.2 → NP_001338413.1  sodium/calcium exchanger 1 isoform F precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92746.1
      UniProtKB/TrEMBL
      E9PB98
      Related
      ENSP00000412560.2, ENST00000417271.2
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 945
      caca; sodium/calcium exchanger 1

    7. NM_001351485.2 → NP_001338414.1  sodium/calcium exchanger 1 isoform F precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC106048
      Consensus CDS
      CCDS92746.1
      UniProtKB/TrEMBL
      E9PB98
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 945
      caca; sodium/calcium exchanger 1

    8. NM_001351486.2 → NP_001338415.1  sodium/calcium exchanger 1 isoform G precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92743.1
      UniProtKB/TrEMBL
      A0A994J7E1
      Related
      ENSP00000516110.1, ENST00000705282.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 944
      caca; sodium/calcium exchanger 1

    9. NM_001351487.2 → NP_001338416.1  sodium/calcium exchanger 1 isoform H precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92745.1
      UniProtKB/TrEMBL
      A0A994J4U7
      Related
      ENSP00000516141.1, ENST00000705603.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 961
      caca; sodium/calcium exchanger 1

    10. NM_001351488.2 → NP_001338417.1  sodium/calcium exchanger 1 isoform H precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC106048
      Consensus CDS
      CCDS92745.1
      UniProtKB/TrEMBL
      A0A994J4U7
      Related
      ENSP00000516109.1, ENST00000705281.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 961
      caca; sodium/calcium exchanger 1

    11. NM_001351489.2 → NP_001338418.1  sodium/calcium exchanger 1 isoform H precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC106048
      Consensus CDS
      CCDS92745.1
      UniProtKB/TrEMBL
      A0A994J4U7
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 961
      caca; sodium/calcium exchanger 1

    12. NM_001351490.2 → NP_001338419.1  sodium/calcium exchanger 1 isoform I precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92744.1
      UniProtKB/TrEMBL
      A0A994J7G2
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 938
      caca; sodium/calcium exchanger 1

    13. NM_001351491.2 → NP_001338420.1  sodium/calcium exchanger 1 isoform I precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92744.1
      UniProtKB/TrEMBL
      A0A994J7G2
      Related
      ENSP00000516143.1, ENST00000705605.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 938
      caca; sodium/calcium exchanger 1

    14. NM_001351492.2 → NP_001338421.1  sodium/calcium exchanger 1 isoform I precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC106048
      Consensus CDS
      CCDS92744.1
      UniProtKB/TrEMBL
      A0A994J7G2
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 938
      caca; sodium/calcium exchanger 1

    15. NM_001351493.2 → NP_001338422.1  sodium/calcium exchanger 1 isoform E precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS59430.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 965
      caca; sodium/calcium exchanger 1

    16. NM_001351494.2 → NP_001338423.1  sodium/calcium exchanger 1 isoform D precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS46264.1
      Related
      ENSP00000383886.1, ENST00000406785.7
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 937
      caca; sodium/calcium exchanger 1

    17. NM_001372263.2 → NP_001359192.1  sodium/calcium exchanger 1 isoform A precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877
      Consensus CDS
      CCDS1806.1
      UniProtKB/Swiss-Prot
      A8K6N1, D6W595, O95849, P32418, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
      Related
      ENSP00000384763.1, ENST00000403092.5
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 973
      caca; sodium/calcium exchanger 1

    18. NM_001394103.1 → NP_001381032.1  sodium/calcium exchanger 1 isoform A precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877
      Consensus CDS
      CCDS1806.1
      UniProtKB/Swiss-Prot
      A8K6N1, D6W595, O95849, P32418, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 973
      caca; sodium/calcium exchanger 1

    19. NM_001394104.1 → NP_001381033.1  sodium/calcium exchanger 1 isoform B precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC106048
      Consensus CDS
      CCDS46265.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 968
      caca; sodium/calcium exchanger 1

    20. NM_001394105.1 → NP_001381034.1  sodium/calcium exchanger 1 isoform H precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS92745.1
      UniProtKB/TrEMBL
      A0A994J4U7
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 961
      caca; sodium/calcium exchanger 1

    21. NM_001394106.1 → NP_001381035.1  sodium/calcium exchanger 1 isoform D precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS46264.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 937
      caca; sodium/calcium exchanger 1

    22. NM_001394107.1 → NP_001381036.1  sodium/calcium exchanger 1 isoform D precursor

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC106048
      Consensus CDS
      CCDS46264.1
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 937
      caca; sodium/calcium exchanger 1

    23. NM_021097.5 → NP_066920.1  sodium/calcium exchanger 1 isoform A precursor

      See identical proteins and their annotated locations for NP_066920.1

      Status: VALIDATED

      Source sequence(s)
      AC007254, AC007281, AC007377, AC007877, AC106048
      Consensus CDS
      CCDS1806.1
      UniProtKB/Swiss-Prot
      A8K6N1, D6W595, O95849, P32418, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
      Related
      ENSP00000332931.4, ENST00000332839.9
      Conserved Domains (1) summary
      TIGR00845
      Location:4 → 973
      caca; sodium/calcium exchanger 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      40097270..40512435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      40106262..40521419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32418.3 GenPept UniProtKB/Swiss-Prot:P32418

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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