MMP9 matrix metallopeptidase 9 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: MMP9provided by VGNC
Official Full Name: matrix metallopeptidase 9provided by VGNC
Primary source: VGNC:VGNC:96422
See related: Ensembl:ENSSSCG00000007436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in lung (RPKM 1.3), spleen (RPKM 1.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	17	NC_010459.5 (48179690..48186782)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	17	NC_010459.4 (53819971..53827064)

Chromosome 17 - NC_010459.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MMP9 was expressed in all the tissues (heart, liver, spleen, lung, kidney, stomach, duodenum, jejunum, ileum, and colon) analyzed. The A allele at the g.48178429 G>A locus and the G allele at rs336583561 are resistance alleles in Min pigs.
Title: Expression pattern and association analysis of porcine matrix metallopeptidase 9 (MMP9) with diarrhea and performance traits in piglets.
MMP9 and VEGF, but not MMP13 or FGF23 may have roles in bone lesions in the hypovitaminosis D kyphotic pig model
Title: Gene expression of matrix metalloproteinase 9 (MMP9), matrix metalloproteinase 13 (MMP13), vascular endothelial growth factor (VEGF) and fibroblast growth factor 23 (FGF23) in femur and vertebra tissues of the hypovitaminosis D kyphotic pig model.
Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.
Title: Timing and duration of nursing from birth affect neonatal porcine uterine matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1.
Increased MMP-9 expression is associated with carotid atherosclerotic plaque.
Title: Matrix metalloproteinase-9 expression in carotid atherosclerotic plaque and contrast-enhanced MRI in a swine model.
For A3011G, the GG genotype was associated with a significantly higher (p < 0.05) number of live births than those recorded for AA sows and the additive effect was significant
Title: Characterization and association analysis with litter size traits of porcine matrix metalloproteinase-9 gene (pMMP-9).
Increased expression of MMP-9 is associated with intraplaque hemorrhage in a swine model of vulnerable carotid atherosclerosis
Title: Overexpression of matrix metalloproteinase-9 is correlated with carotid intraplaque hemorrhage in a swine model.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.
Title: Expression and complex formation of MMP9, MMP2, NGAL, and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with tachycardia-induced systolic heart failure.
Data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.
Title: Gelatinases (MMP2 and MMP9) in swine antral follicle.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
Title: Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
Title: Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase-9

Names: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9

NP_001033093.1

EC 3.4.24.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038004.1 → NP_001033093.1 matrix metalloproteinase-9 precursor

See identical proteins and their annotated locations for NP_001033093.1

Status: PROVISIONAL

Source sequence(s)

DQ132879

UniProtKB/TrEMBL

A0A287AZD5, A0A4X1U0W0, A0A8D1BD38, A0A8D1NMV6, Q2VI03

Related

ENSSSCP00000049256.1, ENSSSCT00000049521.3

Conserved Domains (6) summary

smart00059
Location:280 → 328

FN2; Fibronectin type 2 domain

cd00094
Location:515 → 705

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:114 → 443

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:114 → 443

Peptidase_M10; Matrixin

pfam01471
Location:40 → 93

PG_binding_1; Putative peptidoglycan binding domain

pfam04886
Location:473 → 507

PT; PT repeat