ireb2 iron-responsive element binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ireb2provided by ZNC
Official Full Name: iron-responsive element binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-051205-1
See related: Ensembl:ENSDARG00000021466 AllianceGenome:ZFIN:ZDB-GENE-051205-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7153062
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and iron-responsive element binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in blood and presumptive blood. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (6227830..6261679, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (6100428..6134302, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in citrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain