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    Csf2ra colony stimulating factor 2 receptor subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 652957, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Csf2raprovided by RGD
    Official Full Name
    colony stimulating factor 2 receptor subunit alphaprovided by RGD
    Primary source
    RGD:1594330
    See related
    EnsemblRapid:ENSRNOG00000049782 AllianceGenome:RGD:1594330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable granulocyte colony-stimulating factor binding activity and granulocyte colony-stimulating factor receptor activity. Involved in response to ethanol. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RA (colony stimulating factor 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 57.3), Lung (RPKM 48.3) and 9 other tissues See more
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    Genomic context

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    See Csf2ra in Genome Data Viewer
    Location:
    14p22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (113219..118808, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (98089..103261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (1462292..1467264)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481808 Neighboring gene protein phosphatase 2, regulatory subunit B'', beta Neighboring gene rCG57257-like Neighboring gene karyopherin subunit alpha 1, pseudogene 2 Neighboring gene cytokine receptor-like factor 2 Neighboring gene vomeronasal 2 receptor, pseudogene 123

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. Rosas M, et al. Eur J Immunol, 2007 Sep. PMID 17694571, Free PMC Article
    2. GM-CSF receptor expression and signaling is decreased in lungs of ethanol-fed rats. Joshi PC, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Dec. PMID 16877635
    3. Cloning of rat interleukin-3 receptor beta-subunit from cultured microglia and its mRNA expression in vivo. Appel K, et al. J Neurosci, 1995 Aug. PMID 7643220, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in granulocyte-macrophage colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    granulocyte-macrophage colony-stimulating factor receptor subunit alpha
    Names
    colony stimulating factor 2 receptor alpha subunit
    colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
    granulocyte-macrophage colony stimulating receptor alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037660.1 → NP_001032749.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_001032749.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ628424
      UniProtKB/TrEMBL
      M0R536, Q701L2
      Conserved Domains (2) summary
      cd00063
      Location:221 → 314
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:125 → 217
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      113219..118808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273580.1 → XP_063129650.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

      UniProtKB/TrEMBL
      Q701L2

    2. XM_063273582.1 → XP_063129652.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

    3. XM_063273578.1 → XP_063129648.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    4. XM_063273581.1 → XP_063129651.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    5. XM_063273583.1 → XP_063129653.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X7

    6. XM_063273579.1 → XP_063129649.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    7. XM_039092399.2 → XP_038948327.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X8

      Conserved Domains (1) summary
      pfam09240
      Location:127 → 217
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    8. XM_017599372.3 → XP_017454861.2  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAL6, M0R536
      Related
      ENSRNOP00000075442.2, ENSRNOT00000077243.3
      Conserved Domains (1) summary
      pfam09240
      Location:127 → 217
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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