Kcnip1 potassium voltage-gated channel interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnip1provided by RGD
Official Full Name: potassium voltage-gated channel interacting protein 1provided by RGD
Primary source: RGD:70886
See related: EnsemblRapid:ENSRNOG00000005365 AllianceGenome:RGD:70886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kchip1
Summary: Enables calcium ion binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in positive regulation of action potential. Located in dendrite and neuronal cell body. Part of potassium channel complex. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 29.7), Testes (RPKM 11.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (18723726..19093025, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (18219519..18588833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (18558128..18942677, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KChIP1 plays a neuroprotective role against 4-AP acute induced cell death in primary hippocampal cells through regulation of Kv 4.3 and GABA transmission but this is lost after long term exposure.
Title: Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
This study demonistrared that the expression and function of KCHIP1 channels in neurons of the rat bed nucleus of the stria terminalis.
Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
KChIP1 is selectively expressed in BLA interneurons where it may function to regulate the activity of A-type potassium channels. Hence, KChIP1 might be considered as a specific regulator of GABAergic inhibitory circuits in the basolateral amygdala.
Title: Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.
Aph1b and KCnIP1 are significantly differentially expressed in a number of brain tissues of a schizophrenia model; KCnIP1 is an attractive novel candidate gene that may play a role in the complex phenotype
Title: Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.
PUFAs inhibit Kv4/KChIP channels by facilitating inactivation from open and closed gating states and access of the fatty acid to the internal leaflet of the membrane is important
Title: Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels.
KChIPs have an essential role in determining both the biophysical and molecular characteristics of Kv4 channels
Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.
KChIP1 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability..
Title: KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.
The features of KChIP1b modulation of Kv4 channels are likely to be conserved in mammals and demonstrate a role for the KChIP1 NH2-terminal region in the regulation of closed inactivation gating.
Title: Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels.
hypothesis that occlusion of the inner vestibule of the Na(+) channel by the fast inactivation gate inhibits ultra-slow inactivation (mu1 sodium channel)
Title: Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046920 (e-PCR)
- UniSTS:111014

BF405894 (e-PCR)
- UniSTS:247974

Kcnip1 (e-PCR), detects polymorphism
- UniSTS:478914

AA849706 (e-PCR)
- UniSTS:250308

RH142383 (e-PCR)
- UniSTS:231630

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Kv4.3-KChIP1 channel complex	IEA Inferred from Electronic Annotation more info
part_of Kv4.3-KChIP1 channel complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: A-type potassium channel modulatory protein KCNIP1; Kv channel-interacting protein 1

Names: A-type potassium channel modulatory protein 1; potassium channel-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001261387.1 → NP_001248316.1 A-type potassium channel modulatory protein KCNIP1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K701, A0A0H2UHE0, A0A0H2UHY1

Related

ENSRNOP00000046697.3, ENSRNOT00000040737.4

Conserved Domains (2) summary

COG5126
Location:59 → 225

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:146 → 217

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001261388.1 → NP_001248317.1 A-type potassium channel modulatory protein KCNIP1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 1.

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K701, A0A8I6ALG6

Related

ENSRNOP00000094374.1, ENSRNOT00000120110.2

Conserved Domains (1) summary

COG5126
Location:48 → 214

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001261389.2 → NP_001248318.1 A-type potassium channel modulatory protein KCNIP1 isoform 3

See identical proteins and their annotated locations for NP_001248318.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q793P9, Q8CIR1, Q8R425, Q8R426

UniProtKB/TrEMBL

A0A0G2K701

Related

ENSRNOP00000007187.5, ENSRNOT00000007187.7

Conserved Domains (1) summary

COG5126
Location:50 → 216

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_022929.3 → NP_075218.2 A-type potassium channel modulatory protein KCNIP1 isoform 4

See identical proteins and their annotated locations for NP_075218.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K701, A6HDH0

Related

ENSRNOP00000074006.2, ENSRNOT00000083090.3

Conserved Domains (1) summary

COG5126
Location:39 → 205

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]