Tgm4 transglutaminase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgm4provided by RGD
Official Full Name: transglutaminase 4provided by RGD
Primary source: RGD:620785
See related: EnsemblRapid:ENSRNOG00000004320 AllianceGenome:RGD:620785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dp1
Summary: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within mating plug formation. Predicted to be located in Golgi apparatus. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human TGM4 (transglutaminase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 36.2), Kidney (RPKM 24.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (131566887..131603920)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (122689429..122726463)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (132117279..132157485)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF416391 (e-PCR)
- UniSTS:249267

BE112987 (e-PCR)
- UniSTS:246254

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mating plug formation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein-glutamine gamma-glutamyltransferase 4

Names: TGase-4; dorsal prostate transglutaminase; dorsal protein 1; glutamine gamma-glutamyltransferase 4; transglutaminase 4 (prostate)

NP_073204.2

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022713.2 → NP_073204.2 protein-glutamine gamma-glutamyltransferase 4

See identical proteins and their annotated locations for NP_073204.2

Status: VALIDATED

Source sequence(s)

BC066665, CA339697, DN931716, DN934649

UniProtKB/Swiss-Prot

Q6NYB5, Q99041

UniProtKB/TrEMBL

A6I4A2, Z4YP11

Related

ENSRNOP00000052677.4, ENSRNOT00000055822.5

Conserved Domains (4) summary

smart00460
Location:249 → 341

TGc; Transglutaminase/protease-like homologues

COG1305
Location:252 → 373

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam00868
Location:8 → 116

Transglut_N; Transglutaminase family

pfam00927
Location:571 → 667

Transglut_C; Transglutaminase family, C-terminal ig like domain