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    Septin7 septin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64551, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Septin7provided by RGD
    Official Full Name
    septin 7provided by RGD
    Primary source
    RGD:620469
    See related
    EnsemblRapid:ENSRNOG00000006545 AllianceGenome:RGD:620469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdc10; Sept7
    Summary
    A structural constituent of postsynapse. Involved in postsynapse organization. Is active in glutamatergic synapse and postsynaptic septin cytoskeleton. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 1102.5), Heart (RPKM 763.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Septin7 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (31995597..32059069)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (23719448..23783247)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (26412910..26476615)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351664 Neighboring gene triosephosphate isomerase 1 like 1 Neighboring gene ribosomal protein S6, pseudogene 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene endonuclease/exonuclease/phosphatase family domain containing 1 Neighboring gene uncharacterized LOC108351840

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of proteins in the postsynaptic density fraction by mass spectrometry. Walikonis RS, et al. J Neurosci, 2000 Jun 1. PMID 10818142, Free PMC Article
    2. A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks. Ewers H, et al. PLoS One, 2014. PMID 25494357, Free PMC Article
    3. Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons. Tada T, et al. Curr Biol, 2007 Oct 23. PMID 17935993, Free PMC Article
    4. The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology. Xie Y, et al. Curr Biol, 2007 Oct 23. PMID 17935997
    5. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Nakatsuru S, et al. Biochem Biophys Res Commun, 1994 Jul 15. PMID 8037772

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that diffusion of receptors and bulk membrane, but not cytoplasmic proteins, is slower in spines bearing Sept7 at their neck. Finally, when Sept7 expression was suppressed by RNA interference, membrane molecules explored larger membrane areas. Our findings indicate that Sept7 regulates membrane protein access to spines
      Title: A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks.
    2. The data indicate that septin 7 hinders GLUT4 storage vesicle trafficking and further, the interaction of septin 7 with nephrin in glomeruli suggests that septin 7 may participate in the regulation of glucose transport in podocytes.
      Title: Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
    3. Knockdown of SEPT5 or SEPT7 in developing hippocampal neurons impaired axon growth.
      Title: Characterization of presynaptic septin complexes in mammalian hippocampal neurons.
    4. localizes at the bases of filopodia and at branch points in developing hippocampal neurons
      Title: The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology.
    5. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption.
      Title: Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of postsynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables structural constituent of postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cortical cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pseudopodium retraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic septin cytoskeleton EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic septin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic septin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in septin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in septin filament array ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septin ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    septin-7
    Names
    CDC10 (cell division cycle 10, S.cerevisiae, homolog)
    CDC10 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113740.1 → NP_001107212.1  septin-7 isoform b

      See identical proteins and their annotated locations for NP_001107212.1

      Status: VALIDATED

      Source sequence(s)
      BC128738, CA512303, EV764168
      UniProtKB/Swiss-Prot
      Q9WVC0
      UniProtKB/TrEMBL
      A2VCW8, D4A0F5
      Related
      ENSRNOP00000059464.4, ENSRNOT00000063967.5
      Conserved Domains (2) summary
      cd01850
      Location:47 → 317
      CDC_Septin; CDC/Septin GTPase family
      PRK12704
      Location:337 → 433
      PRK12704; phosphodiesterase; Provisional

    2. NM_022616.2 → NP_072138.2  septin-7 isoform a

      See identical proteins and their annotated locations for NP_072138.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9WVC0
      Related
      ENSRNOP00000008839.8, ENSRNOT00000008838.9
      Conserved Domains (2) summary
      cd01850
      Location:46 → 316
      CDC_Septin; CDC/Septin GTPase family
      PRK12704
      Location:336 → 432
      PRK12704; phosphodiesterase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      31995597..32059069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266076.1 → XP_063122146.1  septin-7 isoform X1

      UniProtKB/TrEMBL
      A6JYB9
      Related
      ENSRNOP00000071177.3, ENSRNOT00000081574.3

    2. XM_039082087.2 → XP_038938015.1  septin-7 isoform X1

      UniProtKB/TrEMBL
      A6JYB8, A6JYB9
      Related
      ENSRNOP00000098762.1, ENSRNOT00000169086.1
      Conserved Domains (2) summary
      cd01850
      Location:1 → 264
      CDC_Septin; CDC/Septin GTPase family
      PRK12704
      Location:284 → 380
      PRK12704; phosphodiesterase; Provisional

    3. XM_063266077.1 → XP_063122147.1  septin-7 isoform X1

      UniProtKB/TrEMBL
      A6JYB9

    4. XM_039082088.2 → XP_038938016.1  septin-7 isoform X2

      Conserved Domains (2) summary
      cd01850
      Location:1 → 165
      CDC_Septin; CDC/Septin GTPase family
      PRK12704
      Location:185 → 269
      PRK12704; phosphodiesterase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVC0.1 GenPept UniProtKB/Swiss-Prot:Q9WVC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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