Sncg synuclein, gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sncgprovided by RGD
Official Full Name: synuclein, gammaprovided by RGD
Primary source: RGD:70996
See related: EnsemblRapid:ENSRNOG00000058006 AllianceGenome:RGD:70996
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alpha-tubulin binding activity and beta-tubulin binding activity. Involved in several processes, including cellular response to hydrostatic pressure; response to cocaine; and response to desipramine. Located in axon terminus; neuronal cell body; and perinuclear region of cytoplasm. Biomarker of depressive disorder and glaucoma. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 555.6), Thymus (RPKM 212.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (9706765..9712072, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (9700513..9705751, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (10722110..10726648, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Title: Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects.
Title: A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.
Studies characterized sites of GlcNAcylation on neuronal proteins tau, synucleins, and methyl CpG-binding protein 2.
Title: Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry.
the homeostatic level of Syn G in RGC-5 cells is required for transcriptional regulation of protein kinases and phosphatases, controlling phosphorylation of Bad and 14-3-3
Title: Effect of gamma-synuclein silencing on apoptotic pathways in retinal ganglion cells.
gamma-Synuclein is selectively and abundantly expressed in human retinal ganglion cells (RGCs) in vivo, primary rat RGCs in vitro, and immortalized RGC-5 cells.
Title: Gamma-synuclein as a marker of retinal ganglion cells.
Coinjection of lentiviruses expressing DAT and gamma-synuclein - leading to overexpression of both proteins in the NAc - resulted in a strong increase in cocaine-induced rat locomotor activity suggesting a synergetic role of both proteins.
Title: The role of gamma-synuclein in cocaine-induced behaviour in rats.
For gamma-synuclein, levels increased significantly only in the cerebral cortex and only from 5 d to 1 mo of age;levels in the cerebellum were very high at 5 d and significantly reduced at 1 mo of age.
Title: Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats.
Gamma-synuclein lacks a C-terminal domain that causes nuclear localisation of the fusion protein, suggesting that the two synucleins might have different roles relating to the cell nucleus.
Title: Subcellular localisation of recombinant alpha- and gamma-synuclein.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in aggressive behavior	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrostatic pressure	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to desipramine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-synuclein

Names: persyn; sensory neuron synuclein; synuclein, gamma (breast cancer-specific protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031688.2 → NP_113876.2 gamma-synuclein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2K0T6, A6KFS0

Related

ENSRNOP00000075051.2, ENSRNOT00000080635.3

Conserved Domains (1) summary

pfam01387
Location:1 → 105

Synuclein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

9706765..9712072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094809.2 → XP_038950737.1 gamma-synuclein isoform X2

UniProtKB/TrEMBL

A0A0G2K0T6, A6KFS0

Conserved Domains (1) summary

pfam01387
Location:1 → 105

Synuclein
XM_063275691.1 → XP_063131761.1 gamma-synuclein isoform X1