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    Pdcl phosducin like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64013, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pdclprovided by RGD
    Official Full Name
    phosducin likeprovided by RGD
    Primary source
    RGD:621135
    See related
    EnsemblRapid:ENSRNOG00000008484 AllianceGenome:RGD:621135
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phlp; Pdcl1
    Summary
    Involved in negative regulation of protein refolding and protein folding. Predicted to be located in cilium. Predicted to be active in cytoplasm. Orthologous to human PDCL (phosducin like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 207.2), Lung (RPKM 180.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdcl in Genome Data Viewer
    Location:
    3q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41519953..41529545, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21110165..21119763, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21602349..21609821, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 1 Neighboring gene uncharacterized LOC120101901 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 2 Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. Thibault C, et al. Biochim Biophys Acta, 1999 Mar 19. PMID 10095058
    2. Interaction of phosducin-like protein with G protein betagamma subunits. Thibault C, et al. J Biol Chem, 1997 May 9. PMID 9139665
    3. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Miles MF, et al. Proc Natl Acad Sci U S A, 1993 Nov 15. PMID 8248177, Free PMC Article
    4. Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors. Lai CW, et al. J Neurosci, 2013 May 1. PMID 23637185, Free PMC Article
    5. Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. McLaughlin JN, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060742, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterotrimeric G-protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heterotrimeric G-protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosducin-like protein
    Names
    phosducin-like 1
    NP_071583.1
    XP_038961705.1
    XP_063140566.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022247.2 → NP_071583.1  phosducin-like protein

      See identical proteins and their annotated locations for NP_071583.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q4V8L9, Q63737, Q63738
      UniProtKB/TrEMBL
      A0A8I6A6H0, A6JES8
      Conserved Domains (2) summary
      cd02987
      Location:51 → 272
      Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...
      pfam02114
      Location:35 → 299
      Phosducin; Phosducin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41519953..41529545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105777.2 → XP_038961705.1  phosducin-like protein isoform X2

      UniProtKB/TrEMBL
      A6JES9
      Conserved Domains (1) summary
      pfam02114
      Location:1 → 216
      Phosducin

    2. XM_063284496.1 → XP_063140566.1  phosducin-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q4V8L9, Q63737, Q63738
      UniProtKB/TrEMBL
      A6JES8
      Related
      ENSRNOP00000012160.2, ENSRNOT00000012160.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63737.1 GenPept UniProtKB/Swiss-Prot:Q63737

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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