CCL5 C-C motif chemokine ligand 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCL5provided by HGNC
Official Full Name: C-C motif chemokine ligand 5provided by HGNC
Primary source: HGNC:HGNC:10632
See related: Ensembl:ENSG00000271503 MIM:187011; AllianceGenome:HGNC:10632
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
Summary: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Expression: Broad expression in spleen (RPKM 54.1), lymph node (RPKM 46.2) and 17 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (35871491..35880360, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (36819399..36828268, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (34198495..34207364, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer.
Title: CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer.
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin.
Title: Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin.
Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.
Title: Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.
CCR5 and CCL5 in metastatic colorectal cancer.
Title: CCR5 and CCL5 in metastatic colorectal cancer.
Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.
Title: Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis.
CCL5's Role in Periodontal Disease: A Narrative Review.
Title: CCL5's Role in Periodontal Disease: A Narrative Review.
Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor alpha gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants.
Title: Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor α gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants.
m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.
Title: m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.
The intricate role of CCL5/CCR5 axis in Alzheimer disease.
Title: The intricate role of CCL5/CCR5 axis in Alzheimer disease.
ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression.
Title: ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression.

Submit: New GeneRIF Correction See all GeneRIFs (588)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Susceptibility to HIV infection MedGen: C1836230 OMIM: 609423 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Clinical samples of serum from patients infected with HIV-1 subtypes B and C exhibited upregulated levels of CXCL10 (IP10) and CCL5 (RANTES)	PubMed
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors	PubMed
HIV/tuberculosis coinfection upregulates CCL5 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis)	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 JRFL Env (gp120) binds specifically to polystyrene-immobilized PF4 (CXCL4) and CCL5 (RANTES) as measured through ELISA	PubMed
	env	HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages	PubMed
	env	Curcumin, a potent and safe anti-inflammatory compound, inhibits HIV-1 gp120-mediated upregulation of the proinflammatory cytokines TNF-alpha and IL-6, and the chemokines IL-8, RANTES, and IP-10 in primary human genital epithelial cells	PubMed
	env	The binding of HIV-1 gp120 to CCR5 and entry of macrophage-tropic HIV-1 isolates into cells is blocked by CCR5 antagonists or the chemokine RANTES, which interacts with CCR5	PubMed
	env	HIV-1 gp120-induced neurodegeneration is significantly inhibited by overexpression of CCL5 in vivo	PubMed
	env	HIV-1 gp120-mediated upregulation of CCL5 expression requires the NF-kappaB pathway in astrocytes	PubMed
	env	Exposure of macrophages to purified CCR5- or CXCR4-tropic HIV-1 envelope glycoprotein gp120 induces secretion of high levels of macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, RANTES, and tumor necrosis factor alpha	PubMed
	env	NK cells exposed to CXCR4-tropic HIV-1 gp120 produce lower levels of CC chemokines RANTES, MIP-1alpha, and MIP-1beta compared with that produced from untreated NK cells	PubMed
	env	RANTES, stromal derived factor-1alpha (SDF-1alpha), macrophage-derived chemokine (MDC), and their combination attenuate HIV-1 gp120-induced food and water intake decrease in rats	PubMed
	env	HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES	PubMed
	env	CXCR4-tropic HIV-1 gp120 augments the expression of RANTES, IP-10, MCP-1, and LTN in peripheral blood mononuclear cells (PBMCs), while CCR5-tropic HIV-1 gp120 also induces an increase in both IP-10 and MCP-1 production	PubMed
	env	A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES	PubMed
	env	Chemokines such as fractalkine, macrophage-derived chemokine (MDC), RANTES, and SDF-1alpha are able to block gp120-induced apoptosis of hippocampal neurons; both fractalkine and MDC activate ERK-1/2, while SDF-1alpha activates CREB	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of CCL5 in peptide-treated PBMCs	PubMed
	env	RANTES, MIP-1beta, and anti-CD4 antibodies inhibit CCR5-dependent cell-cell fusion mediated by HIV-1 gp120 and gp41 from macrophage-tropic isolates	PubMed
	env	HIV-1 gp41 stimulates microglial cell production of cytokines (TNF-alpha, IL-1beta, and IL-6) and chemokines (RANTES and MIP-1alpha)	PubMed
Nef	nef	HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples	PubMed
	nef	Knockdown of C/EBPalpha, C/EBPgamma, and AP-1 by siRNA shows significant reduction of CCL5 levels, suggesting that C/EBPalpha, C/EBPgamma, and AP-1 proteins are involved in Nef-mediated upregulation of CCL5	PubMed
	nef	Knockdown of p38 MAPK alpha or delta by siRNA shows significant reduction of CCL5 levels, suggesting that p38 MAPK alpha and delta proteins are involved in Nef-mediated upregulation of CCL5	PubMed
	nef	Knockdown of AKT2 and AKT3 by siRNA shows significant reduction of CCL5 levels, suggesting that AKT2 and AKT3 proteins are involved in Nef-mediated upregulation of CCL5	PubMed
	nef	Knockdown of the p50 and p65 subunits of NF-kappaB shows significant reduction of CCL5 levels, suggesting that NF-kappaB is involved in Nef-mediated upregulation of CCL5	PubMed
	nef	HIV-1 Nef induces a time-dependent CCL5 upregulation in astrocytes	PubMed
	nef	HIV-1 Nef-pulsed iDCs downregulate MIP-1beta and RANTES expression in NK cells	PubMed
	nef	HIV-1 Nef upregulates the production of RANTES/CCL5 in microglial cells	PubMed
Pr55(Gag)	gag	MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells	PubMed
Tat	tat	HIV-1 Tat treatment alone or combination with methadone significantly upregulate RANTES production in mixed-glial cultures	PubMed
	tat	HIV-1 and the viral protein Tat modulate the expression of chemokine (C-C motif) ligand 5 (CCL5; RANTES) in immature dendritic cells and monocyte-derived macrophages	PubMed
	tat	HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins	PubMed
	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of chemokine (C-C motif) ligand 5 (CCL5; RANTES) in primary human brain microvascular endothelial cells	PubMed
	tat	PACAP27-induced release of CCL5 inhibits HIV-1 Tat-mediated toxicity in human astrocytes	PubMed
	tat	Astrocyte cultures treated with morphine and Tat show exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1), RANTES, and IL-6	PubMed
	tat	HIV-1 Tat upregulates RANTES expression in monocyte-derived dendritic cells (MDDC), thereby driving Th1-type immune responses	PubMed
	tat	RANTES inhibits HIV-1 Tat-induced apoptosis, a protective effect mediated by the induction of MCP-1	PubMed
	tat	HIV-1 Tat cooperates with RANTES in inducing monocyte migration	PubMed
	tat	RANTES is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed
	tat	HIV-1 Tat upregulates RANTES expression in human microglial cells, an effect that could contribute to the neuropathogenesis if HIV-1	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of CCL5 (RANTES) in human monocyte-derived dendritic cells	PubMed
	vpr	HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes	PubMed
	vpr	HIV-1 Vpr upregulates expression of CCL5 and causes CCL5 co-localization with GFAP in the cytoplasm of astrocytes	PubMed
	vpr	HIV-1 Vpr regulates expression of RANTES, including upregulation in microglial cells and downregulation in primary lymphocytes and macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D11S2921 (e-PCR)
- UniSTS:152074

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

GDB:607766 (e-PCR)
- UniSTS:158282

L18426 (e-PCR)
- UniSTS:34648

RH39335 (e-PCR)
- UniSTS:89440

G10660 (e-PCR)
- UniSTS:56422

D1S1425 (e-PCR)
- UniSTS:149621

PMC16375P1 (e-PCR)
- UniSTS:271478

Ccl5 (e-PCR), detects polymorphism
- UniSTS:530818

PMC126614P1 (e-PCR)
- UniSTS:270542

PMC126614P2 (e-PCR)
- UniSTS:270543

PMC126614P3 (e-PCR)
- UniSTS:270544

PMC126614P4 (e-PCR)
- UniSTS:270545

PMC126614P5 (e-PCR)
- UniSTS:270546

PMC126614P6 (e-PCR)
- UniSTS:270547

PMC126614P7 (e-PCR)
- UniSTS:270548

PMC116027P1 (e-PCR)
- UniSTS:270306

PMC116027P2 (e-PCR)
- UniSTS:270307

RH103439 (e-PCR)
- UniSTS:97764

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables CCR1 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables CCR1 chemokine receptor binding	TAS Traceable Author Statement more info	PubMed
enables CCR4 chemokine receptor binding	TAS Traceable Author Statement more info	PubMed
enables CCR5 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	NAS Non-traceable Author Statement more info	PubMed
enables chemokine receptor antagonist activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor signaling protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemokine (C-C motif) ligand 5 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	NAS Non-traceable Author Statement more info	PubMed
involved_in dendritic cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in monocyte chemotaxis	IC Inferred by Curator more info	PubMed
involved_in negative regulation by host of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of viral genome replication	TAS Traceable Author Statement more info	PubMed
involved_in regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chronic inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IC Inferred by Curator more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: C-C motif chemokine 5

Names: T-cell specific protein p288; beta-chemokine RANTES; chemokine (C-C motif) ligand 5; eosinophil chemotactic cytokine; regulated upon activation, normally T-expressed, and presumably secreted; small inducible cytokine subfamily A (Cys-Cys), member 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015990.1 RefSeqGene

Range

5014..13883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001278736.2 → NP_001265665.1 C-C motif chemokine 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_001265665.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA443491, AW769950, BG272739, CB111656, CD695497, CR980938, GD136908, HY265548

Consensus CDS

CCDS92290.1

UniProtKB/TrEMBL

A0A075B7C5, A0A494C1Q1

Related

ENSP00000499138.1, ENST00000651122.1

Conserved Domains (1) summary

cl00134
Location:33 → 63

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...
NM_002985.3 → NP_002976.2 C-C motif chemokine 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_002976.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform 1.

Source sequence(s)

AA443491, AA486131, AW769950, BC008600, BG272739, CD695497

Consensus CDS

CCDS11300.1

UniProtKB/Swiss-Prot

O43646, P13501, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99

UniProtKB/TrEMBL

A0A0G2JQ43, B2R5J8, D0EI67

Related

ENSP00000475057.1, ENST00000605140.6

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...