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    Triml2 tripartite motif family-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 622117, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Triml2provided by MGI
    Official Full Name
    tripartite motif family-like 2provided by MGI
    Primary source
    MGI:MGI:3642989
    See related
    Ensembl:ENSMUSG00000091490 AllianceGenome:MGI:3642989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tu4; EG622117
    Summary
    Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Acts upstream of or within response to retinoic acid. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIML2 (tripartite motif family like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 4.9) See more
    Orthologs
    human all
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    Genomic context

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    See Triml2 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (43633500..43646921)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43180463..43193884)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tryptophanyl-tRNA synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21309 Neighboring gene STARR-seq mESC enhancer starr_21310 Neighboring gene tripartite motif family-like 1 Neighboring gene STARR-seq mESC enhancer starr_21312 Neighboring gene STARR-seq mESC enhancer starr_21313 Neighboring gene STARR-seq mESC enhancer starr_21314 Neighboring gene bromodomain adjacent to zinc finger domain, 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_21316 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21317 Neighboring gene STARR-seq mESC enhancer starr_21318 Neighboring gene STARR-seq mESC enhancer starr_21319 Neighboring gene STARR-seq mESC enhancer starr_21325 Neighboring gene zinc finger protein 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Ringel AR, et al. Cell, 2022 Sep 29. PMID 36179666, Free PMC Article
    2. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Kung CP, et al. Mol Cancer Res, 2015 Feb. PMID 25256710, Free PMC Article
    3. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. Kunarso G, et al. BMC Genomics, 2008 Apr 9. PMID 18400104, Free PMC Article
    4. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that TRIML2 is part of a feed-forward loop that activates p53 in cells expressing the R72 variant, particularly after prolonged stress.
      Title: Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase TRIML2
    NP_001153884.1
    NP_001368858.1
    XP_006509536.1
    XP_017168415.1
    XP_030099563.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160412.2 → NP_001153884.1  probable E3 ubiquitin-protein ligase TRIML2

      See identical proteins and their annotated locations for NP_001153884.1

      Status: VALIDATED

      Source sequence(s)
      AC142104
      Consensus CDS
      CCDS52546.1
      UniProtKB/TrEMBL
      B2M0R4, E9PW10
      Related
      ENSMUSP00000148196.2, ENSMUST00000210136.2
      Conserved Domains (3) summary
      COG1196
      Location:55 → 243
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13733
      Location:245 → 418
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl00034
      Location:18 → 58
      Bbox_SF; B-box-type zinc finger superfamily

    2. NM_001381929.1 → NP_001368858.1  probable E3 ubiquitin-protein ligase TRIML2

      Status: VALIDATED

      Source sequence(s)
      AC142104
      UniProtKB/TrEMBL
      B2M0R4, E9PW10
      Related
      ENSMUSP00000147371.2, ENSMUST00000209200.2
      Conserved Domains (3) summary
      COG1196
      Location:55 → 243
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13733
      Location:245 → 418
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl00034
      Location:18 → 58
      Bbox_SF; B-box-type zinc finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      43633500..43646921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312926.3 → XP_017168415.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

      UniProtKB/TrEMBL
      B2M0R4, E9PW10
      Conserved Domains (3) summary
      COG1196
      Location:55 → 243
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13733
      Location:245 → 418
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl00034
      Location:18 → 58
      Bbox_SF; B-box-type zinc finger superfamily

    2. XM_030243703.1 → XP_030099563.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

      Conserved Domains (1) summary
      cl00034
      Location:18 → 58
      Bbox_SF; B-box-type zinc finger superfamily

    3. XM_006509473.2 → XP_006509536.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

      UniProtKB/TrEMBL
      B2M0R5
      Conserved Domains (1) summary
      cd13733
      Location:143 → 316
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    RNA

    1. XR_001778460.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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