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    PDHB pyruvate dehydrogenase E1 subunit beta [ Bos taurus (domestic cattle) ]

    Gene ID: 613610, updated on 18-Aug-2024

    Summary

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    Official Symbol
    PDHBprovided by VGNC
    Official Full Name
    pyruvate dehydrogenase E1 subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:49151
    See related
    BGD:BT14411; Ensembl:ENSBTAG00000021724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PDHB in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (42918475..42923888)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase 2 Neighboring gene potassium channel tetramerization domain containing 6 Neighboring gene PX domain containing serine/threonine kinase like Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene U6 spliceosomal RNA Neighboring gene abhydrolase domain containing 6, acylglycerol lipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular Characterization and Transcriptional Regulation Analysis of the Bovine PDHB Gene. Li A, et al. PLoS One, 2016. PMID 27379520, Free PMC Article
    2. Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex. Ho L, et al. Biochem Biophys Res Commun, 1988 Feb 15. PMID 2829898
    3. Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes. Yamada T, et al. Res Commun Mol Pathol Pharmacol, 2007-2008. PMID 21469508
    4. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate the pyruvate dehydrogenase-E1 beta core promoter to be located 490bp upstream from the transcription initiation site (+1).
      Title: Molecular Characterization and Transcriptional Regulation Analysis of the Bovine PDHB Gene.
    2. Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
      Title: Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Names
    PDHE1-B
    pyruvate dehydrogenase (lipoamide) beta
    pyruvate dehydrogenase E1 beta subunit
    NP_001030512.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035435.3 → NP_001030512.2  pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001030512.2

      Status: PROVISIONAL

      Source sequence(s)
      BC150020
      UniProtKB/Swiss-Prot
      A6QQW6, P11966, Q58CN6
      UniProtKB/TrEMBL
      A0A3Q1MTX8
      Related
      ENSBTAP00000028958.4, ENSBTAT00000028958.6
      Conserved Domains (3) summary
      cd07036
      Location:37 → 203
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PLN02683
      Location:7 → 356
      PLN02683; pyruvate dehydrogenase E1 component subunit beta
      pfam02780
      Location:226 → 349
      Transketolase_C; Transketolase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42918475..42923888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11966.2 GenPept UniProtKB/Swiss-Prot:P11966

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.