CXCL8 C-X-C motif chemokine ligand 8 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: CXCL8provided by VGNC
Official Full Name: C-X-C motif chemokine ligand 8provided by VGNC
Primary source: VGNC:VGNC:100214
See related: Ensembl:ENSMMUG00000060156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: IL8
Orthologs: human all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	5	NC_041758.1 (60071976..60073899, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	5	NC_027897.1 (60954269..60956192, complement)

Chromosome 5 - NC_041758.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress decreased IL-8 gene expression in both CeA lesioned and non-lesioned animals. But, CeA lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.
Title: Stress decreases, while central nucleus amygdala lesions increase, IL-8 and MIP-1alpha gene expression during tissue healing in non-human primates.

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General gene information

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Markers

PMC139207P1 (e-PCR)
- UniSTS:270884

PMC16008P3 (e-PCR)
- UniSTS:271448

G34435 (e-PCR)
- UniSTS:69229

PMC111986P1 (e-PCR)
- UniSTS:270224

PMC316928P1 (e-PCR)
- UniSTS:273061

PMC127826P1 (e-PCR)
- UniSTS:270560

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-8

Names: C-X-C motif chemokine 8; IL-8; chemokine (C-X-C motif) ligand 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032965.1 → NP_001028137.1 interleukin-8 precursor

See identical proteins and their annotated locations for NP_001028137.1

Status: PROVISIONAL

Source sequence(s)

U19849

UniProtKB/Swiss-Prot

P51495, P67813

UniProtKB/TrEMBL

F7HAG0

Related

ENSMMUP00000072289.1, ENSMMUT00000100547.1

Conserved Domains (1) summary

cd00273
Location:31 → 94

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...