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    NHEJ1 non-homologous end joining factor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 610570, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NHEJ1provided by VGNC
    Official Full Name
    non-homologous end joining factor 1provided by VGNC
    Primary source
    VGNC:VGNC:43797
    See related
    Ensembl:ENSCAFG00845028988
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NHEJ1 in Genome Data Viewer
    Location:
    chromosome: 37
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (25652649..25735139, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (26463707..26546065, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (25513157..25595616, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (25557221..25639564, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (25492303..25574670, complement)

    Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094348 Neighboring gene uncharacterized LOC119867963 Neighboring gene Indian hedgehog signaling molecule Neighboring gene proteasome maturation protein-like Neighboring gene uncharacterized LOC111094448 Neighboring gene solute carrier family 23 member 3 Neighboring gene cyclin Pas1/PHO80 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of optic nerve head coloboma in the Nova Scotia Duck Tolling Retriever identifies discordance with the NHEJ1 intronic deletion (collie eye anomaly mutation). Brown EA, et al. Vet Ophthalmol, 2018 Mar. PMID 28702949, Free PMC Article
    2. Cloning, localization and focus formation at DNA damage sites of canine XLF. Koike M, et al. J Vet Med Sci, 2017 Jan 20. PMID 27746407, Free PMC Article
    3. Discrepancy in compliance between the clinical and genetic diagnosis of choroidal hypoplasia in Danish Rough Collies and Shetland Sheepdogs. Fredholm M, et al. Anim Genet, 2016 Apr. PMID 26732749
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHEJ1 intronic deletion is not solely responsible for all optic nerve head colobomas
      Title: Genetic analysis of optic nerve head coloboma in the Nova Scotia Duck Tolling Retriever identifies discordance with the NHEJ1 intronic deletion (collie eye anomaly mutation).
    2. the intronic deletion in NHEJ1 is not the causative mutation but, rather, a marker linked to the locus underlying the choroidal hypoplasia trait in Danish Rough Collies
      Title: Discrepancy in compliance between the clinical and genetic diagnosis of choroidal hypoplasia in Danish Rough Collies and Shetland Sheepdogs.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA end binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase IV complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-homologous end-joining factor 1
    Names
    XRCC4-like factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051841.1 Reference ROS_Cfam_1.0

      Range
      25652649..25735139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038447984.1 → XP_038303912.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Related
      ENSCAFP00845040215.1, ENSCAFT00845051272.1
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    2. XM_038447986.1 → XP_038303914.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    3. XM_038447985.1 → XP_038303913.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049297.1 Alternate UMICH_Zoey_3.1

      Range
      25557221..25639564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038521967.1 → XP_038377895.1  non-homologous end-joining factor 1

      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    2. XM_038521969.1 → XP_038377897.1  non-homologous end-joining factor 1

      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    3. XM_038521968.1 → XP_038377896.1  non-homologous end-joining factor 1

      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

      Range
      25492303..25574670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038650156.1 → XP_038506084.1  non-homologous end-joining factor 1

      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    2. XM_038650158.1 → XP_038506086.1  non-homologous end-joining factor 1

      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    3. XM_038650157.1 → XP_038506085.1  non-homologous end-joining factor 1

      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

      Range
      25513157..25595616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038585774.1 → XP_038441702.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    2. XM_038585777.1 → XP_038441705.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    3. XM_038585776.1 → XP_038441704.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      26463707..26546065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038463829.1 → XP_038319757.1  non-homologous end-joining factor 1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    2. XM_848099.4 → XP_853192.2  non-homologous end-joining factor 1

      See identical proteins and their annotated locations for XP_853192.2

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component

    3. XM_005640671.4 → XP_005640728.1  non-homologous end-joining factor 1

      See identical proteins and their annotated locations for XP_005640728.1

      UniProtKB/TrEMBL
      A0A8C0R8S2, A0A8C0TQV2, A0A8P0STU4, J9P1R2
      Conserved Domains (1) summary
      pfam09302
      Location:12 → 175
      XLF; XLF-Cernunnos, XRcc4-like factor, NHEJ component
    Nucleotide Protein
    Heading Accession and Version

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