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    GCLC glutamate-cysteine ligase catalytic subunit [ Canis lupus familiaris (dog) ]

    Gene ID: 609822, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GCLCprovided by VGNC
    Official Full Name
    glutamate-cysteine ligase catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:41147
    See related
    Ensembl:ENSCAFG00845010300
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See GCLC in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (21495557..21544499, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (20898243..20947109, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (21243198..21292135, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (20996643..21045520, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (21104936..21153860, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene uncharacterized LOC119874272 Neighboring gene uncharacterized LOC111098290 Neighboring gene uncharacterized LOC106559580 Neighboring gene kelch like family member 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate--cysteine ligase catalytic subunit
    XP_038347987.1
    XP_038410254.1
    XP_038474116.1
    XP_038539704.1
    XP_852845.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      21495557..21544499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038683776.1 → XP_038539704.1  glutamate--cysteine ligase catalytic subunit

      UniProtKB/TrEMBL
      A0A8C0QHV3, A0A8I3NES9, A0A8P0N5C9
      Related
      ENSCAFP00845014183.1, ENSCAFT00845018193.1
      Conserved Domains (2) summary
      PRK00087
      Location:22 → 67
      PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      20996643..21045520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492059.1 → XP_038347987.1  glutamate--cysteine ligase catalytic subunit

      Conserved Domains (2) summary
      PRK00087
      Location:22 → 67
      PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      21104936..21153860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618188.1 → XP_038474116.1  glutamate--cysteine ligase catalytic subunit

      Conserved Domains (2) summary
      PRK00087
      Location:22 → 67
      PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      21243198..21292135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554326.1 → XP_038410254.1  glutamate--cysteine ligase catalytic subunit

      UniProtKB/TrEMBL
      A0A8C0QHV3, A0A8I3NES9, A0A8P0N5C9
      Conserved Domains (2) summary
      PRK00087
      Location:22 → 67
      PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      20898243..20947109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_847752.6 → XP_852845.1  glutamate--cysteine ligase catalytic subunit

      UniProtKB/TrEMBL
      A0A8C0QHV3, A0A8I3NES9, A0A8P0N5C9
      Conserved Domains (2) summary
      PRK00087
      Location:22 → 67
      PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1
      pfam03074
      Location:236 → 608
      GCS; Glutamate-cysteine ligase
    Nucleotide Protein
    Heading Accession and Version

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