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    FGF1 fibroblast growth factor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 607724, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FGF1provided by VGNC
    Official Full Name
    fibroblast growth factor 1provided by VGNC
    Primary source
    VGNC:VGNC:52134
    See related
    Ensembl:ENSCAFG00845017942
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    ECGF; aFGF; FGF-1; HBGF-1
    Orthologs
    human mouse all
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    Genomic context

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    See FGF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (37924029..38010951, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (34520400..34607331, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (36617132..36703569, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (35002929..35089106, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (35815172..35902044, complement)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153902 Neighboring gene putative 60S ribosomal protein L32' Neighboring gene F-box only protein 27-like Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene translationally-controlled tumor protein-like Neighboring gene uncharacterized LOC111092054 Neighboring gene uncharacterized LOC111092056

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of GDNF and FGF-1 in Canine Benign Prostatic Hyperplasia: Evidence for a Pathogenetic Role of Neural Growth Factor. Khodamoradi P, et al. J Comp Pathol, 2021 Jan. PMID 33494907
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of GDNF and FGF-1 in Canine Benign Prostatic Hyperplasia: Evidence for a Pathogenetic Role of Neural Growth Factor.
      Title: Overexpression of GDNF and FGF-1 in Canine Benign Prostatic Hyperplasia: Evidence for a Pathogenetic Role of Neural Growth Factor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor 1
    Names
    Acidic fibroblast growth factor
    Endothelial cell growth factor
    Heparin-binding growth factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      37924029..38010951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038658768.1 → XP_038514696.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QGP1, J9NTP4
      Related
      ENSCAFP00845024891.1, ENSCAFT00845031814.1
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. XM_038658767.1 → XP_038514695.1  fibroblast growth factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NV07, A0A8P0TQ08
      Conserved Domains (1) summary
      pfam00167
      Location:52 → 175
      FGF; Fibroblast growth factor

    3. XM_038658769.1 → XP_038514697.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QGP1, J9NTP4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. XM_038658766.1 → XP_038514694.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      35002929..35089106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038469705.1 → XP_038325633.1  fibroblast growth factor 1 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. XM_038469704.1 → XP_038325632.1  fibroblast growth factor 1 isoform X2

      Conserved Domains (1) summary
      pfam00167
      Location:52 → 175
      FGF; Fibroblast growth factor

    3. XM_038469706.1 → XP_038325634.1  fibroblast growth factor 1 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. XM_038469703.1 → XP_038325631.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      35815172..35902044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038594718.1 → XP_038450646.1  fibroblast growth factor 1 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. XM_038594717.1 → XP_038450645.1  fibroblast growth factor 1 isoform X2

      Conserved Domains (1) summary
      pfam00167
      Location:52 → 175
      FGF; Fibroblast growth factor

    3. XM_038594719.1 → XP_038450647.1  fibroblast growth factor 1 isoform X3

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. XM_038594716.1 → XP_038450644.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      36617132..36703569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038530481.1 → XP_038386409.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QGP1, J9NTP4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. XM_038530480.1 → XP_038386408.1  fibroblast growth factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NV07, A0A8P0TQ08
      Conserved Domains (1) summary
      pfam00167
      Location:52 → 175
      FGF; Fibroblast growth factor

    3. XM_038530482.1 → XP_038386410.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QGP1, J9NTP4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. XM_038530479.1 → XP_038386407.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      34520400..34607331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_844181.6 → XP_849274.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QGP1, J9NTP4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. XM_014108102.3 → XP_013963577.1  fibroblast growth factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NV07, A0A8P0TQ08
      Conserved Domains (1) summary
      pfam00167
      Location:52 → 175
      FGF; Fibroblast growth factor

    3. XM_022408930.2 → XP_022264638.1  fibroblast growth factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QGP1, J9NTP4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. XM_022408919.2 → XP_022264627.1  fibroblast growth factor 1 isoform X1

      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18651.1 GenPept UniProtKB/Swiss-Prot:P18651

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