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    ZFAND3 zinc finger AN1-type containing 3 [ Homo sapiens (human) ]

    Gene ID: 60685, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZFAND3provided by HGNC
    Official Full Name
    zinc finger AN1-type containing 3provided by HGNC
    Primary source
    HGNC:HGNC:18019
    See related
    Ensembl:ENSG00000156639 MIM:607455; AllianceGenome:HGNC:18019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEX27
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 29.7), thyroid (RPKM 22.9) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ZFAND3 in Genome Data Viewer
    Location:
    6p21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (37819727..38154624)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (37644497..37979293)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (37787503..38122400)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37663553-37664282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37664283-37665012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37695835-37696335 Neighboring gene MAM domain containing glycosylphosphatidylinositol anchor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37717757-37718578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37730195-37730696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37744227-37744777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37744845-37745776 Neighboring gene Sharpr-MPRA regulatory regions 13021 and 15353 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24480 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:37787069-37787871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17156 Neighboring gene ZFAND3 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17157 Neighboring gene MPRA-validated peak5795 silencer Neighboring gene RNA, 7SL, cytoplasmic 285, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24481 Neighboring gene MPRA-validated peak5796 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:37849025-37849590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:37896413-37896914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17160 Neighboring gene RNA, variant U1 small nuclear 33 Neighboring gene Sharpr-MPRA regulatory region 1536 Neighboring gene ITGAE pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:38087202-38088004 Neighboring gene uncharacterized LOC124901314 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:38105943-38106787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38120813-38121433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38129468-38130436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38135966-38136596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38136597-38137228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:38137229-38137860 Neighboring gene uncharacterized LOC124901315 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:38159455-38159964 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:38159965-38160474 Neighboring gene uncharacterized LOC124901525 Neighboring gene BTB domain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion. Schuster A, et al. Nat Commun, 2020 Dec 11. PMID 33311477, Free PMC Article
    2. Tex27, a gene containing a zinc-finger domain, is up-regulated during the haploid stages of spermatogenesis. de Luis O, et al. Exp Cell Res, 1999 Jun 15. PMID 10366431
    3. Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3. Muller YL, et al. Diabetes Metab Res Rev, 2017 May. PMID 27862917
    4. Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion. Ndiaye FK, et al. Mol Metab, 2017 Jun. PMID 28580277, Free PMC Article
    5. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. Irvin MR, et al. PLoS One, 2011. PMID 21901158, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.
      Title: AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.
    2. ZFAND3 was identified as a type 2 diabetes susceptibility gene. ZFAND3 plays a role in insulin secretion in vitro.
      Title: Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.
    3. Replication of lead type 2 diabetes mellitus SNPs in GLIS3, KCNK16, and ZFAND3 was observed in American Indians. Sex-specific T2DM signals in GLIS3 and ZFAND3, which are distinct from the East Asian GWAS signals, were also identified.
      Title: Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13222, FLJ17799

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 3
    Names
    testis expressed sequence 27
    testis-expressed protein 27
    zinc finger, AN1-type domain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410904.1 → NP_001397833.1  AN1-type zinc finger protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121574, AL133377, AL589655
      Consensus CDS
      CCDS93913.1
      UniProtKB/TrEMBL
      E2QRF5
      Related
      ENSP00000362489.2, ENST00000373391.6

    2. NM_021943.3 → NP_068762.1  AN1-type zinc finger protein 3 isoform 1

      See identical proteins and their annotated locations for NP_068762.1

      Status: VALIDATED

      Source sequence(s)
      AI817165, AL137302, AW023961, BC031481, BP305887
      Consensus CDS
      CCDS4836.1
      UniProtKB/Swiss-Prot
      Q5SZZ0, Q5SZZ1, Q9H8U3
      Related
      ENSP00000287218.4, ENST00000287218.9
      Conserved Domains (2) summary
      pfam01428
      Location:160 → 194
      zf-AN1; AN1-like Zinc finger
      pfam01754
      Location:19 → 36
      zf-A20; A20-like zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      37819727..38154624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514790.3 → XP_011513092.1  AN1-type zinc finger protein 3 isoform X2

      Conserved Domains (1) summary
      pfam01754
      Location:19 → 36
      zf-A20; A20-like zinc finger

    2. XM_017011171.3 → XP_016866660.1  AN1-type zinc finger protein 3 isoform X1

      Conserved Domains (1) summary
      pfam01428
      Location:144 → 178
      zf-AN1; AN1-like Zinc finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      37644497..37979293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356171.1 → XP_054212146.1  AN1-type zinc finger protein 3 isoform X2

    2. XM_054356170.1 → XP_054212145.1  AN1-type zinc finger protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H8U3.1 GenPept UniProtKB/Swiss-Prot:Q9H8U3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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