Fads3 fatty acid desaturase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fads3provided by MGI
Official Full Name: fatty acid desaturase 3provided by MGI
Primary source: MGI:MGI:1928740
See related: Ensembl:ENSMUSG00000024664 AllianceGenome:MGI:1928740
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Acts upstream of or within gene expression and unsaturated fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in nervous system; retina; and thoracic segment skeleton. Orthologous to human FADS3 (fatty acid desaturase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 131.2), genital fat pad adult (RPKM 81.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.33 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10018189..10037477)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10040855..10060113)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FADS3 is a Delta14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.
Title: FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.
strongly expressed in the decidual cells at implantation sites
Title: Decidual expression and regulation of fatty acid desaturase 3 during mouse decidualization.
Fads3 enhances liver-mediated 22:6n-3 synthesis to support brain 22:6n-3 accretion before and during the brain growth spurt.
Title: Fads3 modulates docosahexaenoic acid in liver and brain.
Changes in expression patterns and fatty acid profiles suggest that Fads3AT9 may play a role in the regulation and/or biosynthesis of long chain polyunsaturated fatty acids from precursors.
Title: Alternative splicing generates novel Fads3 transcript in mice.
FADS3 does exist under multiple protein isoforms depending on the mammalian tissues.
Title: The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI464531 (e-PCR)
- UniSTS:164649

D19Mit51 (e-PCR), detects polymorphism
- UniSTS:128394

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within unsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty acid desaturase 3

Names: delta(13) desaturase; delta(13) fatty acid desaturase

NP_068690.3

EC 1.14.19.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021890.3 → NP_068690.3 fatty acid desaturase 3

See identical proteins and their annotated locations for NP_068690.3

Status: VALIDATED

Source sequence(s)

AA981959, AK029318, AK080414, BY227181

Consensus CDS

CCDS29570.1

UniProtKB/Swiss-Prot

Q7TND7, Q8C4Y5, Q8CDZ4, Q9JJE7

UniProtKB/TrEMBL

Q3T9H9, Q3U3X6

Related

ENSMUSP00000111659.3, ENSMUST00000115995.4

Conserved Domains (2) summary

PLN03199
Location:27 → 444

PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional

cd03506
Location:168 → 417

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...