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Ccr2 C-C motif chemokine receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60463, updated on 2-Nov-2024

Summary

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Official Symbol: Ccr2provided by RGD
Official Full Name: C-C motif chemokine receptor 2provided by RGD
Primary source: RGD:620876
See related: EnsemblRapid:ENSRNOG00000063127 AllianceGenome:RGD:620876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity. Involved in several processes, including positive regulation of tumor necrosis factor production; regulation of signal transduction; and response to hyperoxia. Located in perikaryon; perinuclear region of cytoplasm; and primary dendrite. Biomarker of demyelinating disease and periapical periodontitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

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See Ccr2 in Genome Data Viewer

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (132611883..132619106)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (123734465..123742483)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis.
Title: miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis.
Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor (CCR2) are elevated in chronic heart failure facilitating lung monocyte infiltration and differentiation which may contribute to lung fibrosis.
Title: Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor (CCR2) are elevated in chronic heart failure facilitating lung monocyte infiltration and differentiation which may contribute to lung fibrosis.
CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons.
Title: CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons.
CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
Title: CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion.
CCR2 Positron Emission Tomography for the Assessment of Abdominal Aortic Aneurysm Inflammation and Rupture Prediction.
Title: CCR2 Positron Emission Tomography for the Assessment of Abdominal Aortic Aneurysm Inflammation and Rupture Prediction.
Results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.
Title: Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin-Concentrating Hormone and Behavior in Adolescent Offspring.
CCR2 levels were remarkably up-regulated in calcified aortic valve and calcifying primary aortic valvular interstitial cells (AVICs). Silencing CCR2 inhibited the osteoblastic transformation and calcification of AVICs.
Title: CC chemokine receptor 2 functions in osteoblastic transformation of valvular interstitial cells.
CCR2 activation in nociceptive dorsal root ganglia neurons plays a role in the pathogenesis of gastric hyperalgesia associated with diabetic gastropathy.
Title: CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy.
Light exposure led to apoptosis of photoreceptors, which expressed CCL2, accelerating an inflammation-mediated cascade by activating and attracting microglia and monocytes and promoting their secretion of CCL2 in the injured position.
Title: Expression of CCL2 and its receptor in activation and migration of microglia and monocytes induced by photoreceptor apoptosis.
Expressions of CCR2 mRNA began to increase on the 1st day and reached to the peak on the 7th day, but then started to decrease gradually until 28th day.
Title: Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables CCR2 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 12 binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 2 binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 5 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 7 binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 17 cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular defense response	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to antigenic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to wounding	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in macrophage migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in monocyte extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of eosinophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type 2 immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neutrophil clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta T cell extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta T cell extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of astrocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hematopoietic stem cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hematopoietic stem cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immune complex clearance by monocytes and macrophages	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune complex clearance by monocytes and macrophages	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of thymocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thymocyte migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in primary dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-C chemokine receptor type 2

Names: C-C CKR-2; CC-CKR-2; CCR-2; chemokine (C-C motif) receptor 2; chemokine receptor CCR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021866.2 → NP_068638.1 C-C chemokine receptor type 2

See identical proteins and their annotated locations for NP_068638.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

O55193

UniProtKB/TrEMBL

A6I4D2

Related

ENSRNOP00000100016.1, ENSRNOT00000128102.1

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

132611883..132619106

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082063.2 → XP_038937991.1 C-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

O55193

UniProtKB/TrEMBL

A6I4D2

Related

ENSRNOP00000095594.1, ENSRNOT00000100998.2

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039082061.2 → XP_038937989.1 C-C chemokine receptor type 2 isoform X1

UniProtKB/Swiss-Prot

O55193

UniProtKB/TrEMBL

A6I4D2

Related

ENSRNOP00000081733.1, ENSRNOT00000114724.2

Conserved Domains (1) summary

cd15184
Location:57 → 329

7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors