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    SPARC secreted protein acidic and cysteine rich [ Sus scrofa (pig) ]

    Gene ID: 595124, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SPARCprovided by VGNC
    Official Full Name
    secreted protein acidic and cysteine richprovided by VGNC
    Primary source
    VGNC:VGNC:98332
    See related
    Ensembl:ENSSSCG00000017082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in subcutaneous adipose (RPKM 6004.5), ovary (RPKM 1757.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See SPARC in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 16 NC_010458.4 (71368164..71380972)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 16 NC_010458.3 (77576864..77584734, complement)

    Chromosome 16 - NC_010458.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110257252 Neighboring gene uncharacterized LOC110257254 Neighboring gene uncharacterized LOC110257253 Neighboring gene uncharacterized LOC110257227 Neighboring gene FAT atypical cadherin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Mapping of the porcine FBN2, YWHAQ, CNN3, DCN, POSTN, SPARC, RBM39 and GNAS genes, expressed in foetal skeletal muscles. Stratil A, et al. Anim Genet, 2008 Apr. PMID 18162102
    2. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SPARC
    Names
    BM-40
    ON
    basement-membrane protein 40
    osteonectin
    secreted protein acidic and rich in cysteine
    secreted protein, acidic, cysteine-rich (osteonectin)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031794.1 → NP_001026964.1  SPARC precursor

      See identical proteins and their annotated locations for NP_001026964.1

      Status: PROVISIONAL

      Source sequence(s)
      AY963262
      UniProtKB/Swiss-Prot
      P20112, Q4Z8Q2
      UniProtKB/TrEMBL
      A0A4X1TP83, A0A5G2R6P1
      Related
      ENSSSCP00000072749.2, ENSSSCT00000088328.2
      Conserved Domains (3) summary
      cd00252
      Location:151 → 298
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      cd01328
      Location:68 → 149
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      pfam10591
      Location:150 → 284
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010458.4 Reference Sscrofa11.1 Primary Assembly

      Range
      71368164..71380972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20112.2 GenPept UniProtKB/Swiss-Prot:P20112

    Gene LinkOut

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