Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phlpp1provided by RGD
Official Full Name: PH domain and leucine rich repeat protein phosphatase 1provided by RGD
Primary source: RGD:621308
See related: EnsemblRapid:ENSRNOG00000002821 AllianceGenome:RGD:621308
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scop; Phlpp; Plekhe1
Summary: Enables protein serine/threonine phosphatase activity. Involved in several processes, including hippocampus development; protein dephosphorylation; and regulation of intracellular signal transduction. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 95.4), Lung (RPKM 79.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (22823132..23045619)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (22308532..22530978)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (26145989..26394505)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-190-5p Alleviates Myocardial Ischemia-Reperfusion Injury by Targeting PHLPP1.
Title: miR-190-5p Alleviates Myocardial Ischemia-Reperfusion Injury by Targeting PHLPP1.
Downregulation of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation.
Title: Downregulation of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation.
Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy.
Title: Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy.
Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.
Title: Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.
MIR-190B Alleviates Cell Autophagy and Burn-Induced Skeletal Muscle Wasting via Modulating PHLPP1/Akt/FoxO3A Signaling Pathway.
Title: MIR-190B Alleviates Cell Autophagy and Burn-Induced Skeletal Muscle Wasting via Modulating PHLPP1/Akt/FoxO3A Signaling Pathway.
Suppression of host DNA-repair pathways that remove TOP2bcc trigger HSV-1 reactivation. Moreover, perturbation of AKT phosphorylation dynamics by downregulating the PHLPP1 phosphatase led to AKT mis-localization and disruption of DSB-induced HSV-1 reactivation.
Title: TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency.
SCOP/PHLPP1 overexpression in cultured rat cortical neurons had no effect on 24 h cell death after a mechanical stretch-injury
Title: Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice.
TNF-alpha is involved in cardiac PHLPP1 upregulation during reoxygenation, which is mediated by NF-kappaB transcriptional activity
Title: Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion.
Rapid SCOP breakdown is necessary for memory encoding. Early SCOP degradation is specifically catalysed by mu-calpain, whereas late SCOP resynthesis is mediated by m-calpain.
Title: A molecular brake controls the magnitude of long-term potentiation.
Splice variant PHLPP1alpha inhibits protein kinase B (AKT) in hippocampal neurons; in a novel role, splice variant PHLPP1beta promotes AKT activation.
Title: PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH16037 (e-PCR)
- UniSTS:24378

D0Uwm1 (e-PCR)
- UniSTS:518724

AI555189 (e-PCR)
- UniSTS:239952

D13Mco13 (e-PCR)
- UniSTS:240092

RH133278 (e-PCR)
- UniSTS:216561

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in entrainment of circadian clock	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within entrainment of circadian clock	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase C signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell anergy	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell anergy	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PH domain leucine-rich repeat protein phosphatase 1

Names: Circadian Oscillatory Protein (SCOP); PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; SCN circadian oscillatory protein; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; suprachiasmatic nucleus circadian oscillatory protein

NP_067689.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021657.2 → NP_067689.2 PH domain leucine-rich repeat protein phosphatase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q9WTR8

Related

ENSRNOP00000003840.3, ENSRNOT00000003840.5

Conserved Domains (7) summary

smart00332
Location:1131 → 1383

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

PLN00113
Location:602 → 1089

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

PHA03247
Location:237 → 443

PHA03247; large tegument protein UL36; Provisional

cd13322
Location:498 → 594

PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain

sd00033
Location:796 → 816

LRR_RI; leucine-rich repeat [structural motif]

cd17240
Location:424 → 491

RA_PHLPP1; Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1)

cl28922
Location:176 → 224

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold