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    Hpgds hematopoietic prostaglandin D synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58962, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hpgdsprovided by RGD
    Official Full Name
    hematopoietic prostaglandin D synthaseprovided by RGD
    Primary source
    RGD:69251
    See related
    EnsemblRapid:ENSRNOG00000006583 AllianceGenome:RGD:69251
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ptgds2
    Summary
    Predicted to enable several functions, including glutathione transferase activity; metal ion binding activity; and prostaglandin-D synthase activity. Predicted to be involved in glutathione metabolic process and prostaglandin metabolic process. Predicted to act upstream of or within negative regulation of male germ cell proliferation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 1130.0), Thymus (RPKM 141.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hpgds in Genome Data Viewer
    Location:
    4q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (95698265..95727733, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (94368426..94397931, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (95945356..95970666, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 10 Neighboring gene SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1` Neighboring gene oxidized purine nucleoside triphosphate hydrolase-like Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 4 Neighboring gene pyroglutamylated RFamide peptide receptor like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells. Ragolia L, et al. J Biol Chem, 2003 Jun 13. PMID 12684506
    2. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Kanaoka Y, et al. Cell, 1997 Sep 19. PMID 9323136
    3. Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis. Ragolia L, et al. Prostaglandins Other Lipid Mediat, 2007 Feb. PMID 17259069, Free PMC Article
    4. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Inoue T, et al. Nat Struct Biol, 2003 Apr. PMID 12627223
    5. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Kanaoka Y, et al. Eur J Biochem, 2000 Jun. PMID 10824118

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L-PGDS is involved in the balance of VSMC proliferation and apoptosis
      Title: Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells.
    2. Post-translational modification of L-PGDS, by either glycosylation or phosphorylation, enhances its apoptotic activity and inhibits vascular smooth muscle cells hyperproliferation.
      Title: Post-translational modification regulates prostaglandin D2 synthase apoptotic activity: characterization by site-directed mutagenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105397

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prostaglandin-D synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prostaglandin-D synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prostaglandin-D synthase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of male germ cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to nematode IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hematopoietic prostaglandin D synthase
    Names
    GST class-sigma
    H-PGDS
    glutathione S-transferase
    glutathione-dependent PGD synthase
    glutathione-dependent PGD synthetase
    glutathione-requiring prostaglandin D synthase
    prostaglandin D2 synthase 2, hematopoietic
    prostaglandin-H2 D-isomerase
    NP_113832.1
    XP_006236664.1
    XP_006236665.1
    XP_038964225.1
    XP_063142720.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031644.2 → NP_113832.1  hematopoietic prostaglandin D synthase

      See identical proteins and their annotated locations for NP_113832.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087590
      UniProtKB/Swiss-Prot
      O35351, O35543
      UniProtKB/TrEMBL
      A6KF23
      Related
      ENSRNOP00000008826.4, ENSRNOT00000008826.7
      Conserved Domains (2) summary
      cd10295
      Location:82 → 181
      GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
      cd03039
      Location:4 → 73
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      95698265..95727733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236603.5 → XP_006236665.1  hematopoietic prostaglandin D synthase isoform X2

      Conserved Domains (2) summary
      cd10295
      Location:51 → 151
      GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
      cd03039
      Location:4 → 43
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    2. XM_006236602.5 → XP_006236664.1  hematopoietic prostaglandin D synthase isoform X1

      Related
      ENSRNOP00000106939.1, ENSRNOT00000123843.1
      Conserved Domains (3) summary
      PTZ00057
      Location:3 → 198
      PTZ00057; glutathione s-transferase; Provisional
      cd10295
      Location:82 → 182
      GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
      cd03039
      Location:4 → 73
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    3. XM_063286650.1 → XP_063142720.1  hematopoietic prostaglandin D synthase isoform X3

    4. XM_039108297.2 → XP_038964225.1  hematopoietic prostaglandin D synthase isoform X4

      Conserved Domains (2) summary
      cd03039
      Location:4 → 73
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
      cl02776
      Location:82 → 145
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35543.3 GenPept UniProtKB/Swiss-Prot:O35543

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