p2rx3a purinergic receptor P2X, ligand-gated ion channel, 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: p2rx3aprovided by ZNC
Official Full Name: purinergic receptor P2X, ligand-gated ion channel, 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000427-3
See related: Ensembl:ENSDARG00000010477 AllianceGenome:ZFIN:ZDB-GENE-000427-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p2x3; p2rx3; zP2X3; zfP2X3; fb99b08; wu:fb99b08
Summary: Enables extracellularly ATP-gated cation channel activity. Acts upstream of or within cation transport and neurogenesis. Predicted to be integral component of membrane. Predicted to be integral component of nuclear inner membrane. Is expressed in head and nervous system. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (21944274..21959712, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (21647014..21662467, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expressed in overlapping, but unique, patterns of sensory neurons in the developing zebrafish.
Title: Selective labeling of central and peripheral sensory neurons in the developing zebrafish using P2X(3) receptor subunit transgenes.

Submit: New GeneRIF Correction

General gene information

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Markers

fb99b08.x1 (e-PCR)
- UniSTS:187676

fi47a12.x1 (e-PCR)
- UniSTS:197593

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ATP	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P2X purinoceptor 3a

Names: zP2X3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.