her7 hairy and enhancer of split related-7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: her7provided by ZNC
Official Full Name: hairy and enhancer of split related-7provided by ZNC
Primary source: ZFIN:ZDB-GENE-000427-6
See related: Ensembl:ENSDARG00000017917 AllianceGenome:ZFIN:ZDB-GENE-000427-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb715
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within somite specification. Predicted to be active in nucleus. Is expressed in several structures, including liver; margin; mesoderm; presumptive mesoderm; and tail bud. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (68807198..68808485)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (68036531..68037818)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pairing of segmentation clock genes drives robust pattern formation.
Title: Pairing of segmentation clock genes drives robust pattern formation.
Studied source of noise in Zebrafish somite clock counteracted by Notch signalling; found clock desynch'n, in absence of Notch signalling, is due to stochastic dissociation of Her1/7 repressor proteins from oscillating her1/7 autorepressed target genes.
Title: Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling.
Autoregulatory negative-feedback loops of the repressor Her7 dimers can generate synchronized gene expression oscillations in wild-type embryos and reproduce the dynamics of the segmentation oscillator in different mutant conditions.
Title: Short-lived Her proteins drive robust synchronized oscillations in the zebrafish segmentation clock.
loss of her1 or her7 can allow oscillations to continue with unchanged period but with reduced amplitude and impaired synchrony
Title: The elongation rate of RNA polymerase II in zebrafish and its significance in the somite segmentation clock.
the comparison between single her1hu2124 and her7hu2526 mutants and her1hu2124/bea tm98 double mutants suggests independent roles for both her genes in regulation of distinct phases of the segmentation clock.
Title: Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module.
Data define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.
Title: The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.
Oscillations of the somite segmentation clock may be generated by a delayed negative feedback loop in which the products of two Notch target genes, her1 and her7, directly inhibit their own transcription.
Title: Setting the tempo in development: an investigation of the zebrafish somite clock mechanism.
her7 plays a role in coordinating the oscillations of neighboring cells in the presomitic mesoderm
Title: Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish.
her1 and her7, coding for inhibitory gene regulatory proteins, are implicated in genesis of the somitogenesis oscillator.
Title: Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator.
Data show that her7 is required for initiating the expression in the posterior presomitic mesoderm (PSM), while her1 is required to propagate the cyclic expression in the intermediate and anterior PSM.
Title: Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hairy and enhancer of split related-7

Names: her7-protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.