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    ZNF529 zinc finger protein 529 [ Homo sapiens (human) ]

    Gene ID: 57711, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF529provided by HGNC
    Official Full Name
    zinc finger protein 529provided by HGNC
    Primary source
    HGNC:HGNC:29328
    See related
    Ensembl:ENSG00000186020 AllianceGenome:HGNC:29328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.5), endometrium (RPKM 2.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF529 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36543613..36605543, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39218884..39280696, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37034515..37096159, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CTBP2 pseudogene 7 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:37018470-37019180 and GRCh37_chr19:37019181-37019889 Neighboring gene zinc finger protein 260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14527 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14529 Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14530 Neighboring gene zinc finger protein 567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14531 Neighboring gene ZNF567 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article
    4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
    5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1615

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 529

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145649.2 → NP_001139121.1  zinc finger protein 529 isoform a

      See identical proteins and their annotated locations for NP_001139121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC092295, BC036578, BP279443, DA111996
      Consensus CDS
      CCDS54256.1
      UniProtKB/Swiss-Prot
      K7EKE1, Q6P280, Q9H731, Q9HCF7
      Conserved Domains (3) summary
      COG5048
      Location:392 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:38 → 79
      KRAB; KRAB box

    2. NM_001145650.2 → NP_001139122.1  zinc finger protein 529 isoform b

      See identical proteins and their annotated locations for NP_001139122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC092295, BC036578, DA503147
      Conserved Domains (3) summary
      COG5048
      Location:374 → 526
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:20 → 61
      KRAB; KRAB box

    3. NM_001321351.2 → NP_001308280.1  zinc finger protein 529 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC092295, AK025110, BX503547
      Consensus CDS
      CCDS82335.1
      UniProtKB/TrEMBL
      A0A0C4DFR4
      Related
      ENSP00000334695.7, ENST00000334116.7
      Conserved Domains (2) summary
      COG5048
      Location:287 → 439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347 → 367
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001352272.2 → NP_001339201.1  zinc finger protein 529 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC092295, AK025110, BX503547
      Consensus CDS
      CCDS82335.1
      UniProtKB/TrEMBL
      A0A0C4DFR4
      Conserved Domains (2) summary
      COG5048
      Location:287 → 439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347 → 367
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001352273.2 → NP_001339202.1  zinc finger protein 529 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC092295, AK025110, BX503547
      Consensus CDS
      CCDS82335.1
      UniProtKB/TrEMBL
      A0A0C4DFR4
      Conserved Domains (2) summary
      COG5048
      Location:287 → 439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347 → 367
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_020951.5 → NP_066002.3  zinc finger protein 529 isoform a

      See identical proteins and their annotated locations for NP_066002.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC092295, BC036578, BC064690, BX503547
      Consensus CDS
      CCDS54256.1
      UniProtKB/Swiss-Prot
      K7EKE1, Q6P280, Q9H731, Q9HCF7
      Related
      ENSP00000465578.1, ENST00000591340.6
      Conserved Domains (3) summary
      COG5048
      Location:392 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:38 → 79
      KRAB; KRAB box

    RNA

    1. NR_027239.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several 3' exons but includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, as found in variant 1.
      Source sequence(s)
      AK091072, AK094618, AL109722, DA111996
      Related
      ENST00000586458.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36543613..36605543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527164.4 → XP_011525466.1  zinc finger protein 529 isoform X1

      See identical proteins and their annotated locations for XP_011525466.1

      UniProtKB/Swiss-Prot
      K7EKE1, Q6P280, Q9H731, Q9HCF7
      Conserved Domains (3) summary
      COG5048
      Location:392 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:38 → 79
      KRAB; KRAB box

    2. XM_011527165.4 → XP_011525467.1  zinc finger protein 529 isoform X2

      See identical proteins and their annotated locations for XP_011525467.1

      Conserved Domains (3) summary
      COG5048
      Location:374 → 526
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:20 → 61
      KRAB; KRAB box

    3. XM_006723302.5 → XP_006723365.1  zinc finger protein 529 isoform X1

      See identical proteins and their annotated locations for XP_006723365.1

      UniProtKB/Swiss-Prot
      K7EKE1, Q6P280, Q9H731, Q9HCF7
      Conserved Domains (3) summary
      COG5048
      Location:392 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:38 → 79
      KRAB; KRAB box

    4. XM_047439141.1 → XP_047295097.1  zinc finger protein 529 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DFR4

    5. XM_047439140.1 → XP_047295096.1  zinc finger protein 529 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39218884..39280696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321570.1 → XP_054177545.1  zinc finger protein 529 isoform X1

      UniProtKB/Swiss-Prot
      K7EKE1, Q6P280, Q9H731, Q9HCF7

    2. XM_054321571.1 → XP_054177546.1  zinc finger protein 529 isoform X2

    3. XM_054321569.1 → XP_054177544.1  zinc finger protein 529 isoform X1

      UniProtKB/Swiss-Prot
      K7EKE1, Q6P280, Q9H731, Q9HCF7

    4. XM_054321573.1 → XP_054177548.1  zinc finger protein 529 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DFR4

    5. XM_054321572.1 → XP_054177547.1  zinc finger protein 529 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P280.2 GenPept UniProtKB/Swiss-Prot:Q6P280

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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