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    CD274 CD274 molecule [ Sus scrofa (pig) ]

    Gene ID: 574058, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD274provided by VGNC
    Official Full Name
    CD274 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:86404
    See related
    Ensembl:ENSSSCG00000005211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    PDL1
    Expression
    Broad expression in spleen (RPKM 1.1), ovary (RPKM 0.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CD274 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (216646378..216792731, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (242395402..242416220, complement)

    Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S6-like Neighboring gene programmed cell death 1 ligand 2 Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene relaxin 2 Neighboring gene insulin like 6 Neighboring gene Janus kinase 2 Neighboring gene NEDD8-activating enzyme E1 catalytic subunit pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. PD-L1 expression is increased in monocyte derived dendritic cells in response to porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus infections. Richmond O, et al. Vet Immunol Immunopathol, 2015 Nov 15. PMID 26553563
    2. Immunohistochemical localization of phospholipase D1 in the retina of pigs. Lee J, et al. Neurosci Lett, 2006 Apr 10-17. PMID 16376017
    3. Prokaryotic expression of the extracellular domain of porcine programmed death 1 (PD-1) and its ligand PD-L1 and identification of the binding with peripheral blood mononuclear cells in vitro. Zhu YP, et al. Can J Vet Res, 2017 Apr. PMID 28408783, Free PMC Article
    4. Overexpression of programmed death ligands in naturally occurring postweaning multisystemic wasting syndrome. Yue F, et al. Viral Immunol, 2015 Mar. PMID 25594677, Free PMC Article
    5. Porcine PD-L1: cloning, characterization, and implications during xenotransplantation. Jeon DH, et al. Xenotransplantation, 2007 May. PMID 17489864

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1/PD-L1 pathway.
      Title: Prokaryotic expression of the extracellular domain of porcine programmed death 1 (PD-1) and its ligand PD-L1 and identification of the binding with peripheral blood mononuclear cells in vitro.
    2. role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
      Title: PD-L1 expression is increased in monocyte derived dendritic cells in response to porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus infections.
    3. These data suggest that overexpression of PD-L1 and PD-L2 mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
      Title: Overexpression of programmed death ligands in naturally occurring postweaning multisystemic wasting syndrome.
    4. Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
      Title: Immunohistochemical localization of phospholipase D1 in the retina of pigs.
    5. A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
      Title: Porcine PD-L1: cloning, characterization, and implications during xenotransplantation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    programmed cell death 1 ligand 1
    Names
    CD274 antigen
    programmed death ligand 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025221.1 → NP_001020392.1  programmed cell death 1 ligand 1 precursor

      See identical proteins and their annotated locations for NP_001020392.1

      Status: PROVISIONAL

      Source sequence(s)
      AY837780
      UniProtKB/TrEMBL
      A0A0B8RT47, A0A345BT90, A0A4X1W783, A0A5K1U4T1, A0A8D1TXM5, F1SK50, Q4QTK1
      Related
      ENSSSCP00000034275.2, ENSSSCT00000058965.3
      Conserved Domains (2) summary
      smart00410
      Location:28 → 130
      IG_like; Immunoglobulin like
      cl11960
      Location:29 → 130
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

      Range
      216646378..216792731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021083736.1 → XP_020939395.1  programmed cell death 1 ligand 1 isoform X2

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:62 → 141
      Ig; Immunoglobulin domain

    2. XM_021083755.1 → XP_020939414.1  programmed cell death 1 ligand 1 isoform X3

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:38 → 117
      Ig; Immunoglobulin domain

    3. XM_021083728.1 → XP_020939387.1  programmed cell death 1 ligand 1 isoform X1

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:62 → 141
      Ig; Immunoglobulin domain

    4. XM_021083725.1 → XP_020939384.1  programmed cell death 1 ligand 1 isoform X1

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:62 → 141
      Ig; Immunoglobulin domain

    5. XM_021083730.1 → XP_020939389.1  programmed cell death 1 ligand 1 isoform X1

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:62 → 141
      Ig; Immunoglobulin domain

    6. XM_021083760.1 → XP_020939419.1  programmed cell death 1 ligand 1 isoform X3

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:38 → 117
      Ig; Immunoglobulin domain

    7. XM_021083740.1 → XP_020939399.1  programmed cell death 1 ligand 1 isoform X3

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:38 → 117
      Ig; Immunoglobulin domain

    8. XM_021083747.1 → XP_020939406.1  programmed cell death 1 ligand 1 isoform X3

      UniProtKB/TrEMBL
      A0A4X1W8A6
      Conserved Domains (1) summary
      cl11960
      Location:38 → 117
      Ig; Immunoglobulin domain

    9. XM_021083770.1 → XP_020939429.1  programmed cell death 1 ligand 1 isoform X4

      UniProtKB/TrEMBL
      A0A345BT90, A0A8D0RS56, A0A8D2BPU4
      Conserved Domains (1) summary
      cl11960
      Location:62 → 141
      Ig; Immunoglobulin domain

    10. XM_005660124.3 → XP_005660181.1  programmed cell death 1 ligand 1 isoform X5

      See identical proteins and their annotated locations for XP_005660181.1

      UniProtKB/TrEMBL
      A0A0B8RT47, A0A345BT90, A0A4X1W783, A0A5K1U4T1, A0A8D1TXM5, F1SK50, Q4QTK1
      Related
      ENSSSCP00000005602.4, ENSSSCT00000005744.6
      Conserved Domains (2) summary
      smart00410
      Location:28 → 130
      IG_like; Immunoglobulin like
      cl11960
      Location:29 → 130
      Ig; Immunoglobulin domain

    11. XM_005660125.3 → XP_005660182.1  programmed cell death 1 ligand 1 isoform X5

      See identical proteins and their annotated locations for XP_005660182.1

      UniProtKB/TrEMBL
      A0A0B8RT47, A0A345BT90, A0A4X1W783, A0A5K1U4T1, A0A8D1TXM5, F1SK50, Q4QTK1
      Conserved Domains (2) summary
      smart00410
      Location:28 → 130
      IG_like; Immunoglobulin like
      cl11960
      Location:29 → 130
      Ig; Immunoglobulin domain

    RNA

    1. XR_002341636.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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