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    slco3a1a solute carrier organic anion transporter family member 3A1a [ Danio rerio (zebrafish) ]

    Gene ID: 569735, updated on 28-Oct-2024

    Summary

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    Official Symbol
    slco3a1aprovided by ZNC
    Official Full Name
    solute carrier organic anion transporter family member 3A1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8662
    See related
    Ensembl:ENSDARG00000018726 AllianceGenome:ZFIN:ZDB-GENE-030131-8662
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slco3a1; wu:fa93e11; si:ch211-196l7.1
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in prostaglandin transport and sodium-independent organic anion transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including female organism; gill; liver; pleuroperitoneal region; and skeletal muscle. Orthologous to human SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slco3a1a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (25073984..25176869, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (25087452..25190337, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 174 member B Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Neighboring gene si:dkeyp-59c12.1 Neighboring gene perilipin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. Meier-Abt F, et al. J Membr Biol, 2005 Dec. PMID 16648940
    2. Effects of chronic perfluorooctanoic acid (PFOA) at low concentration on morphometrics, gene expression, and fecundity in zebrafish (Danio rerio). Jantzen CE, et al. Reprod Toxicol, 2017 Apr. PMID 28143724, Free PMC Article
    3. Relative developmental toxicity of short-chain chlorinated paraffins in Zebrafish (Danio rerio) embryos. Liu L, et al. Environ Pollut, 2016 Dec. PMID 27616648
    4. Microcystin-LR-regulated transcriptome dynamics in ZFL cells. Lu X, et al. Aquat Toxicol, 2019 Jul. PMID 31136897
    5. Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): Phylogenetic analysis and tissue distribution. Popovic M, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Mar. PMID 19931635

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 3A1
    Names
    Oatp3a1
    solute carrier organic anion transporter family, member 3A1
    zOatp3a2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045188.2 → NP_001038653.1  solute carrier organic anion transporter family member 3A1

      Status: PROVISIONAL

      Source sequence(s)
      BX649578, BX901968
      UniProtKB/TrEMBL
      A0A8M1NAF8, Q1LV73
      Related
      ENSDARP00000020823.8, ENSDART00000013363.9
      Conserved Domains (3) summary
      cd06174
      Location:35 → 265
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:449 → 506
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:29 → 614
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      25073984..25176869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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